COMPARISON OF ORAL CHLOROQUINE WITH SYSTEMIC MEGLUMINE ANTIMONIATE IN TREATMENT OF CUTANEOUS LEISHMANIASIS

Authors

  • Muhammad Farooq Combined Military Hospital Peshawar/National University of Medical Sciences (NUMS) Pakistan
  • Muhammad Saad Farooq Nishtar Hospital, Multan Pakistan
  • Arfan Ul Bari Pakistan Naval Ship Shifa Hospital, Karachi/National University of Medical Sciences (NUMS) Pakistan
  • Tariq Mehmood Malik Combined Military Hospital Bahawalpur/National University of Medical Sciences (NUMS) Pakistan

DOI:

https://doi.org/10.51253/pafmj.v71i1.3187

Keywords:

Chloroquine, Leishmaniasis, Meglumine antimoniate, Pentavalent antimonial

Abstract

Objective: To compare the efficacy of oral chloroquine with systemic meglumine antimoniate in treatment of
cutaneous leishmaniasis.

Study Design: Open-label comparative prospective study.

Place and Duration of Study: Study was conducted in the department of Dermatology, Combined Military
Hospital Multan, from Jan to Oct 2018.

Methodology: Fifty adult male patients completed the study. The inclusion criteria for the study were patients
having untreated skin lesions less than 3 months old. Diagnosis was made on the basis of history and clinical
features and was confirmed on histopathological examination. Patients were divided into 2 groups of 25 each,
group A patients received meglumine antimoniate 810mg intramuscularly once a day whereas group B patients
were given oral chloroquine 250mg twice a day. Pre-treatment complete physical examination was done along
with blood complete picture, urine routine examination, liver function tests, renal function tests and electrocadiogram. They were repeated after 2 weeks and at the end of treatment. The efficacy was measured by healing of lesions with a measuring tape.

Results: Fifty patients completed the study. At the end of treatment, among group A patients, 4 (16%) showed
no improvement, 21 (84%) improved; whereas in group B patients, 11 (44%) showed no improvement, 14 (56%)
showed improvement. Percentage reduction in surface area of skin lesions was 77.6% in group A, whereas in
group B, it was 42.7%.

Conclusion: Meglumine antimoniate showed better efficacy than chloroquine but oral chloroquine was also
effective and can be used as an alternative therapy.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Downloads

Published

24-02-2021

How to Cite

Farooq, M., Farooq, M. S., Bari, A. U., & Malik, T. M. (2021). COMPARISON OF ORAL CHLOROQUINE WITH SYSTEMIC MEGLUMINE ANTIMONIATE IN TREATMENT OF CUTANEOUS LEISHMANIASIS. Pakistan Armed Forces Medical Journal, 71(1), 139–44. https://doi.org/10.51253/pafmj.v71i1.3187

Issue

Section

Original Articles

Most read articles by the same author(s)

1 2 3 > >>