COMPARISON BETWEEN THE EFFICACY OF PREGABALIN AND AMITRIPTYLINE IN ALLEVIATING PAIN ASSOCIATED WITH PAINFUL DIABETIC PERIPHERAL NEUROPATHY

Efficacy of Pregabalin And Amitriptyline in Alleviating Pain

  • Irfan Ali Soomro Combined Military Hospital Peshawar Pakistan
  • Fawad Ahmad Combined Military Hospital Peshawar Pakistan
  • Naveed Ahmed 75 Medical Battalion Pakistan
Keywords: Alleviation of pain, Amitriptyline, Painful diabetic peripheral neuropathy, Pregabalin.

Abstract

Objective: To compare the efficacy of pregabalin and amitriptyline in alleviating pain associated with painful diabetic peripheral neuropathy (PDPN).
Study Design: Randomized controlled trial.
Place and Duration of Study: Department of Medicine, Pakistan Naval Ship (PNS) Shifa Karachi, from May 2014 to Nov 2014.
Material and Methods: Six hundred and sixty patients (330 in each group) with PDPN fulfilling the inclusion/exclusion criteria were randomized into groups A & B through consecutive non-probability sampling. Baseline pain scores on visual analogue scale (VAS) from 0-10 were recorded. Group-A was given pregabalin & group-B was given amitriptyline. Response was assessed after 6 weeks using VAS. A reduction of >50% on VAS was labeled efficacious.
Results: Out of 660 patients, 46.36% (n=153) in group-A and 57.88% (n=191) in group-B had effective relief of pain whereas 53.64% (n=177) in group-A and 42.12% (n=139) in group-B had persistent pain. A p-value was calculated as 0.003.
Conclusion: Amitriptyline was significantly more effective for alleviation of pain associated with PDPN when compared with pregabalin.

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Published
2018-10-31
How to Cite
Soomro, I. A., Ahmad, F., & Ahmed, N. (2018). COMPARISON BETWEEN THE EFFICACY OF PREGABALIN AND AMITRIPTYLINE IN ALLEVIATING PAIN ASSOCIATED WITH PAINFUL DIABETIC PERIPHERAL NEUROPATHY. PAFMJ, 68(2), 198-201. Retrieved from https://www.pafmj.org/index.php/PAFMJ/article/view/437
Section
Original Articles