@article{Khan_Imran_Hussain_Jafri_Majid_Sajjad_2018, title={ASSOCIATION OF PLASMA LEPTIN WITH CORONARY ARTERY CALCIUM (CAC) IN ADULTS: Plasma Leptin And Coronary Artery Calcium}, volume={68}, url={https://www.pafmj.org/PAFMJ/article/view/1582}, abstractNote={<p><strong>Objective:</strong> To determine the correlation between leptin and CAC in scores subjects without cardiovascular<br>disease (CVD) risk.<br><strong>Study Design:</strong> Cross sectional study.<br><strong>Place and Duration of Study:</strong> Aga Khan University Hospital, from Mar 2014 to Jun 2015.<br><strong>Material and Methods:</strong> Total 128 subjects were included. The study was approved by ethical review committee.<br>After informed consent a predesigned questionnaire was documented. Subjects without known cardiac disease<br>history, coming for non-contrast CT scan for abdominal indications were included. Leptin levels were measured<br>by Enzyme immunoassay. CAC scores were assessed on a 64 slice non-contrast CT scan. Data analyzed by SPSS<br>version 20.<br><strong>Results:</strong> Total 128 subjects were included with mean age 42.82 ± 13.1 years and 78.1% (n=100) were males. Mean<br>BMI and waist circumference was 27.1 ± 5.4 kg/m2 and 94.8 ± 9.0cm respectively. High median leptin levels were<br>seen in 11.7% (n=15) of study subjects. Leptin levels were also significantly higher in female compared to male<br>[12.5ng/ml (0.3-60.9) vs. 2.5ng/ml (0.1-50); p-value=0.001]. High CAC score was present in 15% (n=19) of study<br>subjects.<br>Statistically significant correlation of leptin was found with waist circumference, (r 0.50; p=0.001), positive<br>correlation with BMI (r 0.51, p<0.05) with higher levels noted in obese subjects compared to overweight and<br>normal BMI subjects [median 7.5ng/ml (0.3-60.9) vs. 3.3ng/ml (0.1-40) & 0.1 ng/ml (0.1-0.1)]; No correlation was<br>found between CAC score and serum leptin levels (r 0.073; p=0.41).<br><strong>Conclusions:</strong> Leptin levels are not correlated with CAC scores in subjects with low CVD risk. However, leptin<br>was significantly higher in females and subjects with increased waist circumference.</p>}, number={1}, journal={Pakistan Armed Forces Medical Journal}, author={Khan, Dr Aysha Habib and Imran, Sheharbano and Hussain, Zainab and Jafri, Lena and Majid, Hafsa and Sajjad, Zaffar}, year={2018}, month={Feb.}, pages={149–53} }