@article{Zainab_Khan_Lodhi_Asad_2020, title={EFFECT OF ALPHA TOCOPHEROL ON CHRONIC STRESS INDUCED DERANGEMENTS INN NEUROPEPTIDEY ON SPRAGUE DAWLEY RATS}, volume={70}, url={https://www.pafmj.org/PAFMJ/article/view/4659}, abstractNote={<p><strong>Objective: </strong>To determine the chronic stress induced decline in plasma Neuropeptide Y (NPY) level and protective effects of Alpha Tocopherol (AT) on maintenance of Neuropeptide Y level.</p> <p><strong>Study Design:</strong> Quasi-experimental study.</p> <p><strong>Place and Duration of Study:</strong> The study settings were Al-Nafees Medical College and animal center of National Institute of Health Islamabad (NIH). Duration of research was one year from May 2015 to May 2016.</p> <p><strong>Methodology:</strong> After taking approval of institutional review board 45 male Sprague Dawley rats with inclusion criteria were chosen and allocated to three groups comprised of n=15. Group I was control, group II restraint stress and group III (restraint stress with supplementation of alpha-tocopherol). After 28 days of restraining stress induction plasma Neuropeptide Y level was determined by sandwich Enzyme Linked Immunosorbent Assay (ELISA).</p> <p><strong>Results:</strong> There was a statistically significant decline (p<0.05) in plasma Neuropeptide Y levels in restraint group as compared to control group and with alpha-tocopherol supplementation group.</p> <p><strong>Conclusion:</strong> Chronic restraint stress induction led to decline in Neuropeptide Y levels and alpha-tocopherol prevented fall in Neuropeptide Y levels.</p>}, number={3}, journal={Pakistan Armed Forces Medical Journal}, author={Zainab, Saadia and Khan, Umar Ali and Lodhi, Ghulam Mustafa and Asad, Munazza}, year={2020}, month={Jun.}, pages={776–80} }