TY - JOUR AU - Khan, Aysha Habib AU - Imran, Sheharbano AU - Furqan, Saira AU - Majid, Hafsa AU - Jafri, Lena AU - Islam, Najmul PY - 2018/10/31 Y2 - 2024/03/29 TI - COMPARISON OF DIAGNOSTIC ACCURACY OF GLYCATED HEMOGLOBIN (HBA1C) AND 2-HOUR POST GLUCOSE FOR DIABETES USING AMERICAN DIABETIC ASSOCIATION (ADA) CUT OFFS IN PAKISTANI POPULATION: Diagnostic Accuracy of Glycated HBA1c and 2-Hour Post Glucose JF - Pakistan Armed Forces Medical Journal JA - PAFMJ VL - 68 IS - 5 SE - Original Articles DO - UR - https://www.pafmj.org/PAFMJ/article/view/2242 SP - 1082-87 AB - <p><strong>Objective</strong>: To determine median HbA1c level in patients screened for DM and compare the diagnostic accuracy<br>of HbA1c with the currently recommended ADA cut off, using 2 hours (h) plasma glucose (2-h PG) post 75 grams<br>oral glucose tolerance test (OGTT) as gold standard.<br>Study Design: Cross sectional study.<br><strong>Place and Duration of Study</strong>: Aga Khan University Hospital Karachi, from Jul 2014 to Nov 2015.<br><strong>Patients and Methods</strong>: Consecutive subjects screened by OGTT for diabetes mellitus (DM) were included. Blood<br>sample for plasma glucose and HbA1c were analyzed on ADVIA 1800.<br><strong>Results</strong>: Total 146 subjects were included with median age 45 (IQR 54.2-35) years; 53% (n=77) being females.<br>Median HbA1c of the study subjects was 6% (IQR 6.6-5.6). Positive correlation was observed between age and<br>HbA1c [5.7% (IQR 6.2-5.3) &lt;40 y, 6.2% (IQR 6.8-5.8) in &gt;40 y subjects; r 0.34, p=0.000). Males had higher HbA1c<br>than females [6.1% (IQR 6.8-5.7) years. 5.9% (IQR 6.4-5.4); r 0.17, p=0.036). HbA1c levels were significantly<br>different amongst the different ethnic groups residing in Pakistan (p-value&lt;0.03). HbA1c was positively<br>correlated with FPG (r=0.59, p-value&lt;0.001) and 2-h PG (r=0.56, p-value&lt;0.001). Sensitivity, specificity, PPV, NPV<br>for HbA1c at cutoff of 6.5% in diagnosing diabetes mellitus (DM) were 70%, 89%, 72% and 80% respectively.<br><strong>Conclusion</strong>: High median HbA1c levels is noted in our subjects. At cut off level of HbA1c ≥6.5%, 70% of subjects<br>with DM were diagnosed using ADA criteria of 2-h PG for diabetes as gold standard. Ethnic differences were also<br>observed in levels of HbA1c. There is a need to define cut off for our population.<br><br></p> ER -