Frequency of SARS-CoV-2 Antibodies in PCR-Positive COVID-19 Patients and High-Risk Exposed Subjects at Multan

Authors

  • Sana Iqbal Janjua Department of Pathology, Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Muhammad Younas Department of Pathology, Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Raja Kamran Afzal Department of Pathology, Combined Military Hospital, Multan/National University of Medical Sciences (NUMS) Pakistan
  • Asma Khan Department of Pathology, Combined Military Hospital, Multan/National University of Medical Sciences (NUMS) Pakistan
  • Farhat Yasmeen Combined Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Muskan Younas Army Medical College/National University of Medical Sciences (NUMS) Rawalpindi Pakistan

DOI:

https://doi.org/10.51253/pafmj.v73i4.8820

Keywords:

Antibody test, Asymptomatic cases, COVID-19, Healthcare workers, PCR, SARS-CoV-2

Abstract

Objective: To investigate the degree of association between Reverse Transcription Polymerase Chain Reaction positivity and  seroconversion after natural COVID-19 infection in Multan, City of Pakistan.

Study Design: Cross-sectional study.

Place and Duration of Study: Combined Military Hospital, Multan Pakistan from Apr 2021 to Sep 2021.

Methodology: In this study, 219 Healthcare Workers with suspected SARS-CoV-2 infection were screened via Reverse Transcription Polymerase Chain Reaction for viral genome, followed by detection of corresponding antibody response in serum samples within ten weeks of their first exposure against spike protein via Chemiluminescence immunoassay.

Results: There was a significant association between positive RT-PCR and detectable corresponding antibodies (p=0.001). However, we found no evidence of an association between age and RT-PCR positivity and between age and detectable antibodies (p=0.874 and 0.842, respectively). Furthermore, results indicated no association between gender and RT-PCR positivity and between gender and detectable antibodies (p=0.536 and 0.285, respectively).

Conclusions: It is concluded that antibody detection against SARS-CoV-2 virus spike protein is a useful laboratory tool for screening for COVID-19 infection.
Keywords: Antibody test, Asymptomatic cases, COVID-19, Healthcare workers, PCR, SARS-CoV-2.

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Published

31-08-2023

How to Cite

Janjua, S. I., Younas, M., Afzal, R. K., Khan, A., Yasmeen, F., & Younas, M. (2023). Frequency of SARS-CoV-2 Antibodies in PCR-Positive COVID-19 Patients and High-Risk Exposed Subjects at Multan. Pakistan Armed Forces Medical Journal, 73(4), 1095–1099. https://doi.org/10.51253/pafmj.v73i4.8820

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