Efficacy of Perineural versus Systemic Dexmedetomidine as an Adjuvant to Bupivacaine for Surgical Anesthesia in Axillary Block

Authors

  • Kaukab Majeed Department of Anesthesia, Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Amran Hafiz Department of Anesthesia, Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Usman Eijaz Malik Department of Anesthesia, Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Fayyaz Hussain Department of Anesthesia, Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Najm Us Saqib Department of Anesthesia, Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Amna Gulraz Department of Anesthesia, Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan

DOI:

https://doi.org/10.51253/pafmj.v73i4.8506

Keywords:

Axillary block, Bupivacaine, Dexmedetomidine

Abstract

Objective: To compare the analgesic effect of different routes of Dexmedetomidine when given as an adjuvant to Bupivacaine in the axillary block for surgical correction of radius fracture.

Study Design: Quasi-experimental study.

Place and Duration of Study: Pak Emirates Military Hospital, Rawalpindi Pakistan, from Sep 2021 to Feb 2022.

Methodology: The patients were divided into two equal groups. Group-A (Perineural Dexmedetomidine) and Group B (Intravenous Dexmedetomidine). Group-A received 1ug/kg Perineural Dexmedetomidine along with 30ml of racemic Bupivacaine (0.5%), and Group-B participants received 1ug per kg intravenous Dexmedetomidine after axillary block with 30ml of 0.5% perineural racemic Bupivacaine. The mean duration of analgesia was the primary outcome, and adverse outcomes and sedation were the secondary outcomes.

Results: The duration of analgesia was greater in the perineural Dexmedetomidine Group, with a mean duration of 610.20±29.92 minutes in comparison to the systemic Dexmedetomidine Group, which was 449±39.010 minutes, with pvalue<0.001. Numerical rating scores were higher, and sedation scores were lower in the perineural Dexmedetomidine Group,
making it a safer choice.

Conclusion: Perineural Dexmedetomidine is superior to intravenous Dexmedetomidine when used as an adjuvant to Bupivacaine in axillary brachial plexus block. It prolongs analgesia and is a safer alternative to intravenous Dexmedetomidine as an adjuvant.

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Published

31-08-2023

How to Cite

Majeed, K., Hafiz, A., Malik, U. E., Hussain, F., Saqib, N. U., & Gulraz, A. (2023). Efficacy of Perineural versus Systemic Dexmedetomidine as an Adjuvant to Bupivacaine for Surgical Anesthesia in Axillary Block. Pakistan Armed Forces Medical Journal, 73(4), 1145–1148. https://doi.org/10.51253/pafmj.v73i4.8506

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