Serum Prolactin as an Early Biomarker for Detection of Gestational Diabetes Mellitus-An Experience at CMH Quetta

Azeema Ahmed; Saima Bashir; Hamid lqbal; Naeema Ahmed; Muhammad Anwar; Javaria Ahsan; Fatima Sana; Khurram Haq Nawaz

doi:10.51253/pafmj.v73i1.8619

Authors

Azeema Ahmed Combined Military Hospital Quetta/National University of Medical Sciences (NUMS) Pakistan
Saima Bashir Combined Military Hospital Quetta/National University of Medical Sciences (NUMS) Pakistan
Hamid lqbal Combined Military Hospital Quetta/National University of Medical Sciences (NUMS) Pakistan
Naeema Ahmed Army Medical College/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Muhammad Anwar Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Javaria Ahsan Combined Military Hospital Quetta/National University of Medical Sciences (NUMS) Pakistan
Fatima Sana Combined Military Hospital Quetta/National University of Medical Sciences (NUMS) Pakistan
Khurram Haq Nawaz Combined Military Hospital Quetta/National University of Medical Sciences (NUMS) Pakistan

DOI:

https://doi.org/10.51253/pafmj.v73i1.8619

Keywords:

Gestational diabetes mellitus, Oral glucose tolerance test, Serum prolactin

Abstract

Objective: To determine the association between elevated serum prolactin and the development of gestational diabetes mellitus in the first trimester.

Study Design: Prospective longitudinal study.

Place and Duration of Study: Pathology Department, Combined Military Hospital, Quetta Pakistan, from Apr 2021 to Mar 2022.

Methodology: One hundred and twenty-one patients had a measurement of serum prolactin in the first trimester, along with an oral glucose tolerance test in the second and third trimester, at the Pathology Department Combined Military Hospital Quetta Pakistan.

Results: In the study group, serum prolactin levels were raised in 51(42.1%) patients in the first trimester. A total of 44(36.3%) patients with raised serum prolactin had impaired oral glucose tolerance tests. A significant association was found between raised serum prolactin and subsequent development of gestational diabetes mellitus in pregnant females.

Conclusion: Serum prolactin can be an important biomarker for early diagnosis and monitoring of gestational diabetes mellitus.