Pregabalin as an Adjunct Analgesic in Multimodal Pain Management in Patients Presenting with Acute Peri-Anal Fissure

Authors

  • Vishal Farid Raza Department of General Surgery, Sir Ganga Ram Hospital, Lahore Pakistan
  • Qaiser Mahmood Department of General Surgery, Sir Ganga Ram Hospital, Lahore Pakistan
  • Iqra Waris Department of General Surgery, Sir Ganga Ram Hospital, Lahore Pakistan
  • Muhammad Shahwaiz Malik Department of General Surgery, Pakistan Institute of Medical Sciences, Islamabad Pakistan
  • Khalid Irshad Department of Surgery, University Hospital Hairmyres, United Kingdom
  • Khalid Javeed Khan Department of General Surgery, Sir Ganga Ram Hospital, Lahore Pakistan

DOI:

https://doi.org/10.51253/pafmj.v73i4.8727

Keywords:

Analgesia, Anal fissure, Pregabalin

Abstract

Objective: To assess whether Pregabalin has a role as an adjunct analgesic in anal fissures along with standard conservative treatment.

Study Design: Quasi-Experimental Study.

Place and Duration of Study: Sir Ganga Ram Hospital, Lahore Pakistan, from Nov 2021 to Mar 2022.

Methodology: Thirty patients that fulfilled the inclusion criteria presenting to the Outpatient Department of General Surgery were enrolled in the study and assigned to either the standard Treatment-Group or the Pregabalin-Group. Patients were given standard treatment consisting of 0.2% topical GTN cream, stool softeners and analgesics in the form of NSAIDs and Paracetamol for their acute anal fissure, or they were given standard treatment with adjunct Pregabalin 50mg twice a day. The numerical pain score was recorded at enrollment after one week of follow-up.

Results: There was a significant difference between the change in visual analogue scores from baseline between both groups, (p-value of 0.008). There was a significant difference between days till maximum pain relief was achieved between the two groups (p-value of 0.01). 29(96.6%) of fissures were caused due to constipation.
Conclusion: Pregabalin provides modest analgesic effects in anal fissures and may be used as an adjunct analgesic in patients with severe pain.

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Published

30-08-2023

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Section

Original Articles

How to Cite

1.
Raza VF, Mahmood Q, Waris I, Malik MS, Irshad K, Khan KJ. Pregabalin as an Adjunct Analgesic in Multimodal Pain Management in Patients Presenting with Acute Peri-Anal Fissure. Pak Armed Forces Med J [Internet]. 2023 Aug. 30 [cited 2024 Jun. 18];73(4):1033-6. Available from: https://www.pafmj.org/PAFMJ/article/view/8727