Association of Various Factors with Restless Leg Syndrome in Patients of Chronic Kidney Disease

Asim  Saleem; Asad  Mahmood; Mohsin  Qayyum; Farrukh  Islam; Muhammad  Waseem; Rehab  Younus

doi:10.51253/pafmj.v75i4.10218

Authors

Asim Saleem Department of Medicine, Combined Military Hospital Sialkot /National University of Medical Sciences (NUMS) Pakistan
Asad Mahmood Department of Medicine, Combined Military Hospital Sialkot /National University of Medical Sciences (NUMS) Pakistan
Mohsin Qayyum Department of Medicine, Combined Military Hospital Sialkot /National University of Medical Sciences (NUMS) Pakistan
Farrukh Islam Department of Medicine, Combined Military Hospital Multan /National University of Medical Sciences (NUMS) Pakistan
Muhammad Waseem Department of Medicine, Combined Military Hospital Multan /National University of Medical Sciences (NUMS) Pakistan
Rehab Younus Department of Medicine, Hayat Memorial teaching Hospital Lahore Pakistan

DOI:

https://doi.org/10.51253/pafmj.v75i4.10218

Keywords:

CKD, Restless leg syndrome, risk factors, RLS prevalence

Abstract

Objective: To explore the association of anemia, stage of chronic kidney disease, diabetes mellitus, age of the patient, and duration of chronic kidney disease/hemodialysis with restless leg syndrome in patients of chronic kidney disease.

Study Design: Cross-sectional study

Place and Duration of Study : Combined Military Hospital Sialkot, Pakistan from Jun to Dec 2022.

Methodology: A total of 250 patients were included in the study. Sampling was done using the nonprobability consecutive sampling technique. Patients’ clinical evaluation was done for restless leg syndrome.

Results: Out of 250 patients, 176(70.4%) were males and 74(29.6%) were females with a mean age of 47.6±12 years. Restless leg syndrome was observed in 82(32.8%) patients with chronic kidney disease. The 59(72.0%) males and 23(28.0%) females had restless leg syndrome. No significant difference among gender, smoking, BMI, alcohol consumption, and restless leg syndrome was observed. Significant difference among age groups, diabetes, anemia, duration, and stages of chronic kidney disease with p-value <0.001 was observed.

Conclusions: Restless leg syndrome is prevalent in chronic kidney disease patients and is associated with anemia, stage of chronic kidney disease, duration of chronic kidney disease, diabetes mellitus, and age of the patient.

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References

1. Kambampati S, Wasim S, Kukkar V, Awad VM, Malik BH. Restless leg syndrome in the setting of patients with end-stage renal disease on hemodialysis: a literature review. Cureus 2020; 12(8). https://doi.org/10.7759/cureus.9965

2. Zhang LY, Ma XY, Lin J, Liu WH, Guo W, Yin L, et al. Prevalence and risk factors of restless legs syndrome in hemodialysis patients. Nat Sci Sleep 2020; 14: 19-27. http://doi.org/10.2147/NSS.S236393

3. Lin XW, Zhang JF, Qiu MY, Ni LY, Yu HL, Kuo SH, et al. Restless legs syndrome in end stage renal disease patients undergoing hemodialysis. BMC Neurol 2019; 19: 1-7. https://doi.org/10.1186/s12883-019-1265-y

4. Huang CW, Lee MJ, Wang LJ, Lee PT, Tu YK, Hsu CW, et al. Comparative efficacy and acceptability of treatments for restless legs syndrome in end-stage renal disease: a systematic review and network meta-analysis. Nephrol Dial Transplant 2020; 35(9): 1609-1618. https://doi.org/10.1093/ndt/gfz097

5. Vlasie A, Trifu SC, Lupuleac C, Kohn B, Cristea MB. Restless legs syndrome: An overview of pathophysiology, comorbidities and therapeutic approaches. Exp Ther Med. 20221; 23(2): 185. https://doi.org/10.3892/etm.2021.11108

6. Bogan RK. Effects of restless legs syndrome (RLS) on sleep. Neuropsychiatr Dis Treat 2006; 2(4): 513-519.

https://doi: 10.2147/nedt.2006.2.4.513

7. Sorbi MH, Issazadegan A, Soleimani E, Mirhosseini H. Prevalence of restless legs syndrome in Iran: A systematic review and meta-analysis. J Community Health Res 2020; 9(3) 192-202. http://doi.org/10.18502/jchr.v9i3.4262

8. Didato G, Di Giacomo R, Rosa GJ, Dominese A, de Curtis M, Lanteri P. Restless legs syndrome across the lifespan: symptoms, pathophysiology, management and daily life impact of the different patterns of disease presentation. Int J Environ Res Public Health. 2020; 17(10): 3658.

https://doi.org/10.3390/ijerph17103658

9. Manconi M, Garcia-Borreguero D, Schormair B, Videnovic A, Berger K, Ferri R,et al. Restless legs syndrome. Nat Rev Dis Primers 20213; 7(1): 80.

https://doi.org/10.1038/s41572-021-00311-z

10. Salib M, Memon AN, Gowda AS, Rallabhandi B, Bidika E, Fayyaz H, et al. Dialysis patients with restless leg syndrome: can we relieve their suffering?. Cureus 2020; 12(8): e10053. https://doi.org/10.7759/cureus.10053

11. Abideen ZU, Mahmud SN, Mushtaq F, Farooq MU, Qasim YF, Hamid Z, et al. Association of hemodialysis inadequacy and duration with restless legs syndrome: A cross-sectional study. Cureus. 2018; 10(5): e2570.

https://doi.org/10.7759/cureus.2570

12. Siddique S, Amin W, Aaraj S, Fatima T, Imran Y, Islam A. Restless leg syndrome (RLS) in end stage renal disease. J Shifa Tameer-millet Uni 2022; 5(1): 28-31.

https://doi.org/10.32593/jstmu/Vol5.Iss1

13. Lin Z, Zhao C, Luo Q, Xia X, Yu X, Huang F. Prevalence of restless legs syndrome in chronic kidney disease: a systematic review and meta-analysis of observational studies. Ren Fail 2016; 38(9): 1335-1346.

https://doi.org/10.1080/0886022X.2016.1227564

14. Safarpour Y, Vaziri ND, Jabbari B. Movement disorders in chronic kidney disease–a descriptive review. J Stroke Cerebrovasc Dis 2021; 30(9): 105408.

https://doi.org/10.1016/j.jstrokecerebrovasdis.2020.105408

15. Riar SK, Leu RM, Turner-Green TC, Rye DB, Kendrick-Allwood SR, McCracken C,et al. Restless legs syndrome in children with chronic kidney disease. Pediatr Nephrol 2013; 28: 773-795.

https://doi.org/10.1007/s00467-013-2408-9

16. Trenkwalder C, Allen R, Högl B, Paulus W, Winkelmann J. Restless legs syndrome associated with major diseases: a systematic review and new concept. Neurol 2016; 86(14): 1336-1343. https://doi.org/10.1212/WNL.0000000000002542

17. Saraji NZ, Hami M, Boostani R, Mojahedi MJ. Restless leg syndrome in chronic hemodialysis patients in Mashhad hemodialysis centers. J Renal Inj Prev 2017; 6(2): 137

https://doi.org/10.15171/jrip.2017.27

18. Becker PM, Novak M. Diagnosis, comorbidities, and management of restless legs syndrome. Curr Med Res Opin 2014; 30(8): 1441-1460.

https://doi.org/10.1185/03007995.2014.918029

19. Beladi-Mousavi SS, Jafarizade M, Shayanpour S, Bahadoram M, Moosavian SM, Houshmand G. Restless legs syndrome: associated risk factors in hemodialysis patients. Nephrourol Mon 2015 Nov; 7(6): e31967

https://doi.org/10.5812/numonthly.31967

20. Yeh P, Walters AS, Tsuang JW. Restless legs syndrome: a comprehensive overview on its epidemiology, risk factors, and treatment. Sleep Breath 2012; 16: 987-1007.

https://doi.org/10.1007/s11325-011-0606-x