Frequency of Deep Venous Thrombosis in Hospitalized Patients
DOI:
https://doi.org/10.51253/pafmj.v76iSUPPL-7.10274Keywords:
Deep venous thrombosis, DVT prevalence, venous thromboembolismAbstract
Objective: To determine the occurrence of deep vein thrombosis (DVT) among hospitalized patients.
Study Design: Prospective observational study
Place and Duration of Study: Pakistan Emirates Military Hospital Rawalpindi, Pakistan from Jul to Dec 2022.
Methodology: Hospitalized patients, aged 12-70 years with different medical conditions and suspicion for DVT were enrolled in the study. Venous Doppler ultrasonography was used to detect deep vein thrombosis. Patients having recent surgical procedure or trauma within the previous three months were not included. The continuous variables including age, weight and number of days in the hospital, were summarized by calculating means and standard deviations. Statistical comparisons between deep venous thrombosis negative and deep venous thrombosis positive patients were performed using the Chi-Square test.
Results: The study included 275 patients in total, out of which 236(86%) were males and 39(14%) females. Ultrasound examination was done for the recruitment of deep venous thrombosis-positive 125(45%) and negative 150(55%) patients. Patients were also divided by clinical presentation. Most of the deep venous thrombosis-positive patients had malignancy/cancer 43(34.4%), nephrotic syndrome 16(12.8%), and paralysis 13(10.4%).
Conclusion: Patients with increased age, prolonged hospital stay, history of malignancy or nephrotic syndrome and prolonged immobilization were found to be at increased risk for deep venous thrombosis, it is recommended that such patients should be considered for deep venous thrombosis prophylaxis with a proper and effective dosage of anticoagulant after weighing risk versus benefit ratio in high risk cases.
Downloads
References
Sridharan M, Ashrani AA. Presentation and Significance of Venous Thromboembolism. Current Management of Venous Diseases: Springer; 2018. p. 245-263.
2. Zhan C, Miller MR. Excess length of stay, charges, and mortality attributable to medical injuries during hospitalization. JAMA 2003;290(14):1868-1874.
https://doi.org/10.1001/jama.290.14.1868
3. Peng Y-H, Lin Y-S, Chen C-H, Tsai K-Y, Hung Y-C, Chen H-J, et al. Type 1 diabetes is associated with an increased risk of venous thromboembolism: A retrospective population-based cohort study. PLoS One 2020;15(1):e0226997.
https://doi.org/10.1371/journal.pone.0226997
4. Nicholson M, Chan N, Bhagirath V, Ginsberg J. Prevention of venous thromboembolism in 2020 and beyond. J Clin Med 2020;9(8):2467.
https://doi.org/10.3390/jcm9082467
5. Khan MA, Pal S, Chinoy MA, Ahmed SK. The frequency of deep vein thrombosis in patients with hip fractures. J Pak Med Assoc 2019;69(1):S21-S4.
6. Majima T, Oshima Y. Venous thromboembolism in major orthopedic surgery. J Nippon Med Sch 2021;88(4):268-272.
https://doi.org/10.1272/jnms.jnms.2021_88-418
7. Esenwa C, Unda SR, Altschul DJ, Patel NK, Malaviya A, Seiden J, et al. The effect of race on composite thrombotic events in patients with COVID-19. Thromb Res 2020;199:10-13.
https://doi.org/10.1016/j.thromres.2020.12.015
8. Rubino R, Imburgia C, Bonura S, Trizzino M, Iaria C, Cascio A. Thromboembolic Events in Patients with Influenza: A Scoping Review. Viruses 2022 ;14(12):2817.
https://doi.org/10.3390/v14122817
9. Lee LH, Nagarajan C, Tan CW, Ng HJ. Epidemiology of Cancer-associated thrombosis in Asia: a systematic review. Front Cardiovasc Med 2021;8:669288.https://doi.org/10.3389/fcvm.2021.669288
10. Henke PK, Kahn SR, Pannucci CJ, Secemksy EA, Evans NS, Khorana AA, et al. Call to action to prevent venous thromboembolism in hospitalized patients: a policy statement from the American Heart Association. Circulation 2020;141(24):e914-e31.
https://doi.org/10.1161/cir.0000000000000769
11. Kakkos S, Kirkilesis G, Caprini JA, Geroulakos G, Nicolaides A, Stansby G, et al. Combined intermittent pneumatic leg compression and pharmacological prophylaxis for prevention of venous thromboembolism. Cochrane Database Syst Rev 2022(1): CD005258.
https://doi.org/10.1002/14651858.cd005258.pub4
12. Sebuhyan M, Mirailles R, Crichi B, Frere C, Bonnin P, Bergeron-Lafaurie A, et al. How to screen and diagnose deep venous thrombosis (DVT) in patients hospitalized for or suspected of COVID-19 infection, outside the intensive care units. J Med Vasc 2020;45(6):334-343.
https://doi.org/10.1016/j.jdmv.2020.08.002
13. MacDougall DA, Feliu AL, Boccuzzi SJ, Lin J. Economic burden of deep-vein thrombosis, pulmonary embolism, and post-thrombotic syndrome. Am J Health Syst Pharm 2006;63(20 Suppl 6):S5-15.
https://doi.org/10.2146/ajhp060388
14. Blix K, Gran OV, Severinsen MT, Cannegieter SC, Jensvoll H, Overvad K, et al. Impact of time since diagnosis and mortality rate on cancer‐associated venous thromboembolism: the Scandinavian Thrombosis and Cancer (STAC) cohort. J Thromb Haemost 2018;16(7):1327-1335.
https://doi.org/10.1111/jth.14130
15. Kerlin BA, Ayoob R, Smoyer WE. Epidemiology and pathophysiology of nephrotic syndrome–associated thromboembolic disease. Clin J Am Soc Nephrol 2012;7(3):513-520.
https://doi.org/10.2215/cjn.10131011
16. Runner RP, Gottschalk MB, Staley CA, Pour AE, Roberson JR. Utilization patterns, efficacy, and complications of venous thromboembolism prophylaxis strategies in primary hip and knee arthroplasty as reported by American Board of Orthopedic Surgery part II candidates. J Arthroplasty 2019;34(4):729-734.
https://doi.org/10.1016/j.arth.2018.12.015
17. Ohmori H, Kanaoka Y, Yamasaki M, Takesue H, Sumimoto R. Prevalence and characteristic features of deep venous thrombosis in patients with severe motor and intellectual disabilities. Ann Vasc Dis 2018;11(3):281-285.
https://doi.org/10.3400/avd.oa.18-00028
18. Nakagawa K, Watanabe J, Suwa Y, Suzuki S, Ishibe A, Ota M, et al. Clinical analysis of preoperative deep vein thrombosis risk factors in patients with colorectal cancer: retrospective observational study. Ann Gastroenterol Surg 2019;3(4):451-458.
https://doi.org/10.1002/ags3.12256
19. Lin RJ, Green DL, Shah GL. Therapeutic anticoagulation in patients with primary brain tumors or secondary brain metastasis. Oncologist 2018;23(4):468-473.
https://doi.org/10.1634/theoncologist.2017-0274
20. Dou F, Zhang Y, Yi J, Zhu M, Zhang S, Zhang D, et al. Association of ALK rearrangement and risk of venous thromboembolism in patients with non-small cell lung cancer: a prospective cohort study. Thromb Res 2020;186:36-41.
https://doi.org/10.1016/j.thromres.2019.12.009
21. Kraaijpoel N, Carrier M. How I treat cancer-associated venous thromboembolism. Blood 2019;133(4):291-298.
https://doi.org/10.1182/blood-2018-08-835595
22. Kimpton M, Wells PS, Carrier M. Apixaban for the prevention of venous thromboembolism in high-risk ambulatory cancer patients receiving chemotherapy: rational and design of the AVERT trial. Thromb Res 2018;164:S124-S9.
https://doi.org/10.1016/j.thromres.2018.01.018
23. Key NS, Khorana AA, Kuderer NM, Bohlke K, Lee AY, Arcelus JI, et al. Venous thromboembolism prophylaxis and treatment in patients with cancer: ASCO clinical practice guideline update. J Clin Oncol 2020;38(5):496-520.
https://doi.org/10.1200/jco.19.01461
24. Haas S. The Role of Low Molecular Weight Heparins for Venous Thromboembolism Prevention in Medical Patients—What Is New in 2019? Hämostaseologie 2019;39(1):62-66.
https://doi.org/10.1055/s-0038-1677522
25. Gashi YNM, Elgenaid SN, Suliman HHA, Abdalrahman IB. Knowledge, attitude and practice of orthopedic registrars toward prophylaxis of venous Thromboembolism”. Int J Curr Res Life Sci2018;7(9):2735-2738
Published
Issue
Section
License
Copyright (c) 2026 Waqas Ahmad, Wasim Alamgir, Amir Rashid, Abdul Rehman Azeem Dar, Bilal Ahmed Kayani, Azka Zainab

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.





