Comparison of Mean Red Cell Distribution Width in Ischemic Heart Disease Patients with and Without Heart Failure

Muhammad Uzair Ijaz Malik; Tariq Bashir Tareen; Mehar Rehman

doi:10.51253/pafmj.v76iSUPPL-9.10539

Authors

Muhammad Uzair Ijaz Malik Department of Medicine, PAC Hospital Kamra/National University of Medical Sciences (NUMS) Pakistan
Tariq Bashir Tareen Department of Medicine, Combined Military Hospital/National University of Medical Sciences (NUMS), Rawalpindi Pakistan
Mehar Rehman Department of Medicine, PAC Hospital Kamra/National University of Medical Sciences (NUMS) Pakistan

DOI:

https://doi.org/10.51253/pafmj.v76iSUPPL-9.10539

Keywords:

Heart Failure, Ischemic Heart Disease (IHD), Mean Red Cell Distribution Width (RDW ).

Abstract

Objective: To compare mean red cell distribution width in ischemic heart disease patients with and without heart failure.

Study Design: Cross Sectional study.

Place and Duration of Study: General Medicine Department, Pakistan Aeronautical Complex Hospital, Kamra Pakistan, from Sep 2021 to Apr 2022.

Methodology: Patients presenting to outpatient department or admitted in general medical ward with diagnosed Ischemic heart disease were included in the study as per the inclusion criteria. Basic demographics (age, gender, height, weight on weighing machine, BMI) were noted. 12 lead ECGs and 2D ECHO were performed on all patients. Presence of heart failure with reduced ejection fraction (<45%) was documented and patients were categorized into heart failure and non-heart failure groups. Mean RDW-CV was noted in all patients for comparison.

Results: In this study a total of One Hundred and fifteen patients were recruited with a mean age of 63.13±10.13 years (normal distribution p>0.05). The mean RDW in ischemic heart disease patients was found to be 15.23±1.04%. The mean RDW was significantly higher among patients with heart failure than those without heart failure i.e., 15.51±1.09% and 14.85±0.83% respectively (p-value 0.005). Similarly, significantly higher mean RDW was noted among advanced heart failure cases when stratified based on ejection fraction (p-value 0.001).

Conclusion A significant difference of mean red cell distribution width was observed in between heart failure patients and non-heart failure patients.

Downloads

Download data is not yet available.

References

1. Mann DL, Chakinala M. Disorders of the heart. In: Kasper DL, Hauser SL, Jameson J, Fauci A, Longo D, Losccalzo J, editors. Harrisons principles of internal medicine. 20th ed. New York: McGraw-Hill; 2018.

2. Groenewegen A, Rutten FH, Mosterd A, Hoes AW. Epidemiology of heart failure. Eur. J. Heart Fail. 2020; 22(8): 1342-1356.

https://doi.org/10.1002/ejhf.1858

3. Martinez-Amezcua P, Haque W, Khera R, Kanaya AM, Sattar N, Lam CS, et al. The upcoming epidemic of heart failure in South Asia. Circ Heart Fail 2020; 13(10): e007218.

https://doi.org/10.1161/CIRCHEARTFAILURE.120.007218

4. Khan Z, Khan B, Hiader I, Khan I, ud Din J, Khan H, et al. Etiology of congestive heart failure at a tertiary care hospital. Rawal Med J 2010; 35(2): 141-144.

5. Murphy SP, Kakkar R, McCarthy CP, Januzzi Jr JL. Inflammation in heart failure: JACC state-of-the-art review. J Am Coll Cardiol 2020; 75(11): 1324-1340.

https://doi.org/10.1016/j.jacc.2020.01.014

6. Sarhene M, Wang Y, Wei J, Huang Y, Li M, Li L, et al. Biomarkers in heart failure: the past, current and future. Heart Fail Rev 2019; 24: 867-903.

https://doi.org/10.1007/s10741-019-09807-z

7. Parizadeh SM, Esfehani RJ, Bahreyni A, Ghandehari M, Shafiee M, Rahmani F, et al. The diagnostic and prognostic value of red cell distribution width in cardiovascular disease; current status and prospective. Biofactors 2019; 45(4): 507-516.

https://doi.org/ 10.1002/biof.1518

8. Lippi G, Turcato G, Cervellin G, Sanchis-Gomar F. Red blood cell distribution width in heart failure: a narrative review. World J Cardiol 2018; 10(2): 6-14.

https://doi: 10.4330/wjc.v10.i2.6

9. Rahamim E, Zwas DR, Keren A, Elbaz-Greener G, Ibrahimli M, Amir O, et al. The ratio of hemoglobin to red cell distribution width: A strong predictor of clinical outcome in patients with heart failure. J Clin Med 2022; 11(3): 886.

https://doi.org/10.3390/jcm11030886

10. Kazmi T, Nagi ML, Razzaq S, Hussnain S, Shahid N, Athar U. Burden of noncommunicable diseases in Pakistan. East Mediterr Health J 2022; 28(11): 798-804.

https://doi.org/10.26719/emhj.22.083

11. Löfström U, Hage C, Savarese G, Donal E, Daubert JC, Lund LH, et al. Prognostic impact of Framingham heart failure criteria in heart failure with preserved ejection fraction. ESC Heart Fail 2019; 6(4): 830-839.

https://doi.org/10.1102/ehf2.12458

12. Briggs C, Bain BJ. Basic Hematological Techniques. In: Bain BJ, Bates I, Laffan MA, Lewis SM, editors. Dacie and Lewis practical hematology. 12th ed. Philadelphia, PA: Elsevier; 2017.

13. Patel KV, Mohanty JG, Kanapuru B, Hesdorffer C, Ershler WB, Rifkind JM. Association of the red cell distribution width with red blood cell deformability. Adv Exp Med Biol 2013; 765: 211-216. https://doi.org/10.1007/978-1-4614-4989-8_29

14. Nagula P, Karumuri S, Otikunta AN, Yerrabandi SR. Correlation of red blood cell distribution width with the severity of coronary artery disease—A single center study. Indian Heart J 2017; 69(6): 757-761. https://doi.org/10.1016/j.ihj.2017.04.007

15. Abrahan IV LL, Ramos JD, Cunanan EL, Tiongson MD, Punzalan FE. Red cell distribution width and mortality in patients with acute coronary syndrome: a meta-analysis on prognosis. Cardiol Res 2018; 9(3): 144-152.

https://doi.org/10.14740/cr732w

16. Liu S, Wang P, Shen PP, Zhou JH. Predictive values of red blood cell distribution width in assessing severity of chronic heart failure. Med Sci Monit 2016; 22: 2119-2125.

https://doi.org/10.12659/msm.898103

17. Kim M, Lee CJ, Kang HJ, Son NH, Bae S, Seo J, et al. Red cell distribution width as a prognosticator in patients with heart failure. ESC Heart Fail 2023; 10(2): 834-845.

https://doi.org/10.1002/ehf2.14231

18. Hou H, Sun T, Li C, Li Y, Guo Z, Wang W, et al. An overall and dose-response meta-analysis of red blood cell distribution width and CVD outcomes. Sci Rep 2017; 7: 43420.

https://doi.org/10.1038/srep43420

19. Felker GM, Allen LA, Pocock SJ, Shaw LK, McMurray JJ, Pfeffer MA et al. Red cell distribution width as a novel prognostic marker in heart failure: data from the CHARM program and the Duke databank. J Am Coll Cardiol 2007; 50(1): 40–47.

https://doi.org/10.1016/j.jacc.2007.02.067

20. Melchio R, Rinaldi G, Testa E, Giraudo A, Serraino C, Bracco C, et al. Red cell distribution width predicts mid-term prognosis in patients hospitalized with acute heart failure: the RDW in Acute Heart Failure (RE-AHF) study. Intern Emerg Med 2019; 14: 239-247. https://doi.org/10.1007/s11739-018-1958-z