Association of CHA2DS2-VASc-HSF Score with Severity of Coronary Artery Disease in Patients with Non-ST Elevation Myocardial Infarction

Abstract

Objective: To find association between CHA2DS2-VASc-HSF score and severity of Coronary Artery Disease (CAD), assessed
by Gensini score in Non-ST Elevation Myocardial Infarction (NSTEMI) patients.

Study Design: Analytical Cross-sectional study.

Place and Duration of Study: Armed Forces Institute of Cardiology/National Institute of Heart Disease, Rawalpindi Pakistan, from Jan to Jul 2023.

Methodology: Total one hundred and forty-seven patients were included using non-probability consecutive sampling. For the purpose of study, participants having NSTEMI, confirmed by elevated biomarkers, who had coronary angiography, were
included in the study. ANOVA, Chi-square and Pearson Correlation were applied to find the significance level of study
findings. p<0.05 was taken as statistically.

Results: Out of one hundred and forty-seven participants, most of the patients were male 104(70.7%). The CHA2DS2-VAScHSF score showed a moderate positive correlation (r=0.422, p<0.001) with the Gensini score, indicating that as the CHA2DS2- VASc-HSF score increased, the severity of coronary artery disease also tended to increase. It was observed that with increasing age, severity of CAD significantly increased (p<0.001), while ejection fraction decreased with rising extent of CAD (p=0.01).Moreover, a rising disease burden as indicated by number of diseased, critical and total vessels was associated with higher Gensini score, consequently increased severity of CAD (p<0.001).

Conclusion: This research study supported the potential clinical utility of CHA2DS2-VASc-HSF as an adjunctive tool for risk
stratification in CAD.