Association of Serial Beta Human Chorionic Gonadotropin and Serum Progesterone Levels with Outcome in Pregnancy of Unknown Location

Mehwish Adnan; Sobia  Hanif; Mahpara  Tariq; Qurat ul Ain  Aslam; Shakila  Parveen; Salisa

doi:10.51253/pafmj.v76iSUPPL-5.10805

Authors

Mehwish Adnan Department of Gyney & OBS, Pak Emirates Military Hospital/National University of Medical Sciences (NUMS), Rawalpindi Pakistan
Sobia Hanif Department of Gyney & OBS, Pak Emirates Military Hospital/National University of Medical Sciences (NUMS), Rawalpindi Pakistan
Mahpara Tariq Department of Gyney & OBS, Pak Emirates Military Hospital/National University of Medical Sciences (NUMS), Rawalpindi Pakistan
Qurat ul Ain Aslam Department of Gyney & OBS, Pak Emirates Military Hospital/National University of Medical Sciences (NUMS), Rawalpindi Pakistan
Shakila Parveen Department of Gyney & OBS, Pak Emirates Military Hospital/National University of Medical Sciences (NUMS), Rawalpindi Pakistan
Salisa Department of Gyney & OBS, Pak Emirates Military Hospital/National University of Medical Sciences (NUMS), Rawalpindi Pakistan

DOI:

https://doi.org/10.51253/pafmj.v76iSUPPL-5.10805

Keywords:

Beta hCG; Pregnancy of unknown location; Progesterone; Outcome

Abstract

Objective: To explore the association of serial Beta hCG and serum progesterone levels with outcome in women with pregnancy of unknown location managed at a teaching hospital.

Study Design: Prospective observational study

Place And Duration Of Study: Department of Gynecology and obstetrics Pak Emirates Military Hospital Rawalpindi, Pakistan from Jun 2022 to Jul 2023

Methodology: All the women who were diagnosed as having pregnancy of unknown location by consultant obstetrician based on ultrasound findings were recruited in the study. Serum progesterone and Beta hCG levels were carried out at baseline and then beta HCG levels were repeated at 48 hours. Study participants were followed up for 10 weeks to look for immediate intrauterine outcome of pregnancy. All statistical analysis was performed by using the Statistics Package for Social Sciences.

Results: Out of 101 women with pregnancy of unknown location, 44(43.6%) were primiparous while 57(56.4%) were multiparous. Mean age of women recruited in this study was 27.82 ±4.28 years. At the end of 10 weeks of gestation on transvaginal scan, 38(37.6%) had intrauterine pregnancy, 14(13.8%) had ectopic pregnancy, 35(34.6%) had failed/failing pregnancy while 14(13.8%) had persistent pregnancy of unknown location. Statistical analysis showed that progesterone levels of >10ng/ml and beta hCG ratio ...

Conclusion: Serum Progesterone levels of more than 10 ng/ml and ratio of beta hCG levels at 48 hours and at baseline >60% had statistically significant association

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