Comparative Efficacy of topical 5% Potassium Hydroxide and Liquid Nitrogen in the Treatment of Plane Warts
DOI:
https://doi.org/10.51253/pafmj.v76i4.10812Keywords:
Cryotherapy Liquid nitrogen, Potassium Hydroxide, WartsAbstract
Objective: To study the efficacy while comparing Potassium Hydroxide 5% with Liquid Nitrogen in treatment of plane warts.
Study Design: Randomized-controlled trial (ClinicalTrials.gov: NCT05895071)
Place and Duration of Study: Department of Dermatology, CMH-Abbottabad Pakistan, from Nov 2022 to April 2023.
Methodology: The sample size of 60 patients (aged 4 to 30 years was randomly assigned into two Groups i.e. from 60 patients, in Group-A 30 were advised topical 5%-Potassium Hydroxide solution on affected area once at night upto 4 weeks and in Group-B 30 patients were treated with cryotherapy using Liquid Nitrogen on cotton bud once every two weeks. Patients were reassessed at every two weeks and final assessment was done at 12th week whereas follow up was done every three months for recurrence. The treatment final outcome which categorized complete recovery on complete disappearance of warts with normalization of skin markings.
Results: In Group-A (mean age 15.70+7.35 years) 24 (80%) patients whereas IN Group-B (mean age 16.40+7.81years) 14 (46.7%) patients recovered completely. The 02 (6.7%) patients of Group A and 6(20.0%) patients of Group-B showed no response, rest of patients showed partial response to the treatment having significant p-value 0.003. There was no patient reported with recurrence of warts in Group A while in Group B 4(13.3%) patients. There is not any drop outs.
Conclusions: The Topical 5% KOH showed significant better response. Its treatment adherence is better as compared to the Liquid Nitrogen therapy and reporting lesser side effects.
Downloads
References
1. Ozaydin-Yavuz G, Bilgili S, Guducuoglu H, Yavuz I, Elibuyuk-Aksac S, Karadag A. Determinants of hgh-risk human papillomavirus infection in anogenital warts. Postepy Dermatol Alergol 2019; 36(1): 76-81. https://doi.org/10.5114/ada.2019.82915
2. Nofal A, Elmonsef A, Ragab E, Elkholy BM. An Overview of Various Lines in The Treatment of Warts. Egypt J Hosp Med 2022; 86(1): 570-573. https://doi.org/10.21608/ejhm.2022.215111
3. Abeck D, Tetsch L, Lüftl M, Biedermann T. Extragenital cutaneous warts–clinical presentation, diagnosis and treatment. J Dtsch Dermatol Ges 2019; 17(6): 613-634. https://doi.org/10.1111/ddg.13878
4. Oganesyan A, Sivesind T, Dellavalle R. From the Cochrane Library: Topical Treatments for Cutaneous Warts. J Med Internet Res 2021 ; 4(2): e33900. https://doi.org/10.2196/33900
5. Gerlero P, Hernández-Martín Á. Update on the treatment of molluscum contagiosum in children. Actas Dermosifiliogr 2018; 109(5): 408-415. https://doi.org/10.1016/j.ad.2018.01.007
6. Makki MA, Abdel-Aleem H, Saddik M. Clinical Efficacy of Potassium Hydroxide 10% for the Treatment of Common Warts. Int J Med 2022 ; 4(7): 2503-2506. https://doi.org/10.21608/IJMA.2022.147626.1478
7. Bharti AC, Singh T, Bhat A, Pande D, Jadli M. Therapeutic startegies for human papillomavirus infection and associated cancers. Front Biosci 2018; 10(1): 15-73. https://doi.org/10.2741/e808
8. Singh S, Neema S. Comparison of electrosurgery by electrodessication versus cryotherapy by Liquid Nitrogen spray technique in the treatment of plantar warts. Med J Armed Forces India 2020; 76(2): 156-160. https://doi.org/10.1016%2Fj.mjafi.2018.11.005
9. Reddy EM, Rajashekar TS, Kumar KS, Reddy ME, Rajashekar TS. A Comparative Study of Intralesional Acyclovir vs Immunotherapy for Treatment of Viral Warts. Cureus 2023; 15(5): e38781. https://doi.org/10.7759%2Fcureus.38781
10. Shaikh AM, Mehta MM, Chawan VV. Evaluation of reporting of CONSORT flow diagrams in randomized controlled trials in a national and international pharmacology journal. Perspect Clin Res 2019; 10(4): 168. https://doi.org/10.4103/picr.picr_73_18
11. Bruggink SC, Gussekloo J, Berger MY, Zaaijer K, Assendelft WJ, de Waal MW, et al. Cryotherapy with Liquid Nitrogen versus topical salicylic acid application for cutaneous warts in primary care: randomized controlled trial. Can Med Assoc J 2010; 182(15): 1624-1630. https://doi.org/10.1503/cmaj.092194
12. Al-Hamdi KI, Al-Rahmani MA. Evaluation of topical Potassium Hydroxide solution for treatment of plane warts. Indian J Dermatol 2012 ; 57(1): 38. https://doi.org/10.4103/0019-5154.92675
13. Alamgir AN. Biotechnology, in vitro production of natural bioactive compounds, herbal preparation, and disease management (treatment and prevention). In Therapeutic Use of Medicinal Plants and their Extracts. Springer; 2018.
14. Tripathi A, Sahu U. An overview of HPV: Causes, symptoms, and clinical manifestations. Immunopathology, Diagnosis and Treatment of HPV Induced Malignancies. Academic Press;2022.
15. Khattab FM, Khashaba SA. Evaluation of combined treatment with long-pulsed neodymium-doped yttrium aluminum garnet laser and Potassium Hydroxide for the treatment of recalcitrant wart: a prospective comparative study. J Dermatolog Treat 2020; 31(1): 56-60. https://doi.org/10.1080/09546634.2019.1618436
16. Ahmed I, Agarwal S, Ilchyshyn A, Charles‐Holmes S, Berth‐Jones J. Liquid Nitrogen cryotherapy of common warts: cryo‐spray vs. cotton wool bud. Br J Dermatol 2001; 144(5): 1006-1009. https://doi.org/10.1046/j.1365-2133.2001.04190.x
17. Galal EA, Ali MM, Ali MS. Comparative study between Potassium Hydroxide 5% and Liquid Nitrogen in treatment of plane warts. Sci J Al-Azhar Med 2020; 4(4): 644. https://doi.org/10.4103/sjamf.sjamf_83_20
18. Jayaprasad S, Subramaniyan R, Devgan S. Comparative evaluation of topical 10% Potassium Hydroxide and 30% trichloroacetic acid in the treatment of plane warts. Indian J Dermatol 2016 ; 61(6): 634. https://doi.org/10.4103%2F0019-5154.193670
Downloads
Published
Issue
Section
License
Copyright (c) 2026 Sana Aslam, Bushra Muzaffar, Muhammad Adeel Siddiqui, Majid Hussain, Zahra Nigar, Sara Ilyas
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
