Role of Autologous Platelet Rich Plasma in Timely Healing of Chronic Diabetic Foot Ulcer

Muhammad Faaiz Ul  Marram; Waseem Ahmad  Khan; Muhammad  Imran; Waleed  Umer; Zahoor Muhi Ud  Deen; Fahad Nazir  Malik

doi:10.51253/pafmj.v75i2.11669

Authors

Muhammad Faaiz Ul Marram Department of General Surgery, Combined Military Hospital Rawalpindi/National University of Medical Sciences (NUMS) Pakistan
Waseem Ahmad Khan Department of General Surgery, Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Muhammad Imran Department of General Surgery, Combined Military Hospital Rawalpindi/National University of Medical Sciences (NUMS) Pakistan
Waleed Umer Department of General Surgery, Combined Military Hospital Rawalpindi/National University of Medical Sciences (NUMS) Pakistan
Zahoor Muhi Ud Deen Department of General Surgery, Combined Military Hospital Rawalpindi/National University of Medical Sciences (NUMS) Pakistan
Fahad Nazir Malik Department of General Surgery, Combined Military Hospital Rawalpindi/National University of Medical Sciences (NUMS) Pakistan

DOI:

https://doi.org/10.51253/pafmj.v75i2.11669

Keywords:

Diabetic foot ulcers, Platelet-rich plasma, Wound healing

Abstract

Objective: To evaluate the efficacy of platelet-rich plasma in treating chronic non-healing diabetic foot ulcers, in comparison to conventional dressings.

Study Design: Quasi-experimental study.

Place and Duration of Study: General Surgery Department of Combined Military Hospital Rawalpindi, Pakistan from Jun- Dec 2023.

Methodology: A comparative study was conducted on patients with persistent non-healing diabetic foot ulcers. The study participants were split up into two groups. In Group-A, platelet-rich plasma was injected into the ulcer's base and the wound's borders. In Group-B, the ulcer was treated with saline-soaked moist dressings. Every patient underwent two months of follow-up, with planned follow-up visits on 7th, 14th, 30th, 45th, and 60th days. Autologous PRP's effectiveness in treating chronic diabetic foot ulcers was compared with conventional dressings.

Results: Mean age of 120 patients was 55.98±9.71 years. 108(90%) were males and 12(10%) were females. At the end of two months, 53(88.8%) patients from Group-A showed a significant reduction in wound grade as compared to 28(46%) patients from Group-B (p=<0.001). Furthermore, 48(80%) patients from Group-A experienced complete wound healing after 02 months as compared to 14(23.3%%) patients from Group-B (p=<0.001)

Conclusion: Treating chronic non-healing diabetic foot ulcers with Autologous Platelet-Rich Plasma is associated with better and expedited wound healing.

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