Intra-Operative Wound Irrigation with Normal Saline Solution Versus Topical Antibiotics to Avoid Wound Infection
DOI:
https://doi.org/10.51253/pafmj.v74i1.11737Keywords:
Appendectomy, Anti-bacterial agents, Wounds and Injuries, Surgical wound infection, Imipenem, CilastatinAbstract
Objective: To compare intra-operative wound irrigation with normal saline versus irrigation with Imipenem and Cilastatin
solution to develop surgical site infections in open appendectomy wounds.
Study Design: Quasi-experimental study.
Place and Duration of Study: Department of Surgery, Combined Military Hospital, Bahawalnagar Pakistan, from Oct 2015 to Oct 2017.
Methodology: Patients diagnosed with cases of acute appendicitis and planned to undergo open appendectomy were
randomly divided into two equal groups; Group-A and Group-B. Group-A was subjected to intra-operative wound irrigation
with 100 ml saline solution before skin closure. Group-B was irrigated with Imipenem and Cilastatin solution (500 mg diluted
in 10ml of distilled water). Development of post-operative Surgical Site Infection was checked till the 30th Post-Operative Day.
Results: Frequency of post-operative Surgical Side infection was comparatively less in Group-B (2.4%) as compared to GroupA (8%), which was found to be statistically significant (p-value=0.046)
Conclusion: Intra-operative wound irrigation with Imipenem and Cilastatin solution was superior to normal saline irrigation
regarding the development of Surgical Site Infection in cases undergoing open appendectomy.
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