Per-Operative Administration of Benzodiazepine in Preventing Post-Operative Nausea and Vomiting In Patients Segregated According to the APFEL Score

Muhammad Ali Abbas; Muhammad Ehsan Zafar; Khalid Ameer; Sanum Kashif; Moazzam Ali; Muhammad Huzaifa

doi:10.51253/pafmj.v76iSUPPL-9.12319

Authors

Muhammad Ali Abbas Department of Anesthesia, Combined Military Hospital Rawalpindi /National University of Medical Sciences (NUMS) Pakistan
Muhammad Ehsan Zafar Department of Anesthesia, Combined Military Hospital Rawalpindi /National University of Medical Sciences (NUMS) Pakistan
Khalid Ameer Department of Anesthesia, Combined Military Hospital Rawalpindi /National University of Medical Sciences (NUMS) Pakistan
Sanum Kashif Department of Anesthesia, Combined Military Hospital Rawalpindi /National University of Medical Sciences (NUMS) Pakistan
Moazzam Ali Department of Anesthesia, Combined Military Hospital Rawalpindi /National University of Medical Sciences (NUMS) Pakistan
Muhammad Huzaifa Department of Anesthesia, Combined Military Hospital Rawalpindi /National University of Medical Sciences (NUMS) Pakistan

DOI:

https://doi.org/10.51253/pafmj.v76iSUPPL-9.12319

Keywords:

APFEL, Benzodiazepine, nausea, post-operative, vomiting

Abstract

Objective: To compare the incidence of post-operative nausea and vomiting in patients with and without administration of peri-operative Benzodiazepine segregated according to the APFEL scoring system

Study Design: Quasi-experimental study

Place and Duration of Study: Anesthesia Department, Combined Military Hospital, Rawalpindi Pakistan from Jan 2023 to Dec 2023.

Methodology: Patients were divided into Group B (n=140) being given per-operative Benzodiazepine along with standard anti-emetic prophylaxis and Group N (n=140) being given standard anti-emetic prophylaxis alone after excluding patients with risk factors according to the APFEL score. Primary variables studied were the incidence of nausea and vomiting in patients assessed at 1,3,6,12, and 24 hours. Secondary variable studied was mean time post-surgery to discharge.

Results: Comparison of primary variables revealed incidence of nausea/vomiting in patients between Group B and Group N at 1 hour post-operatively was 21(15%) versus 27(19.3%) patients (p=0.341), assessed at 3 hour post-operatively was 13(9.3%) versus 15(10.7%) patients (p=0.690), assessed at 6 hour post-operatively was 08(5.7%) versus 10(7.1%) patients (p=0.626), assessed at 12 hours was 05(3.6%) versus 06(4.3%) patients and at 24 hours was 07 (5.0%) versus 09(6.4%) patients (p=0.609). Mean duration of hospital stay between both Groups post-surgery till discharge was 72.18±4.15 hours for Group B versus 81.92±4.25 hours for Group N (p=0.609).

Conclusion: We conclude that low risk patients according to Apfel criteria show no significant change in the incidence of PONV with the addition of Benzodiazepine to standard anti-emetic protocol.

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