Case Report of Adult Pulmonary Blastoma:  Very rare presentation

Authors

  • Asma Asghar Department of Radiology, Shaukat Khanam Memorial Cancer Hospital, Lahore Pakistan
  • Muhammad Haris Rauf Department of Radiology, Shaukat Khanam Memorial Cancer Hospital, Lahore Pakistan
  • Ali Zafar Sheikh Department of Radiology, Shaukat Khanam Memorial Cancer Hospital, Lahore Pakistan
  • Kashif Siddique Department of Radiology, Shaukat Khanam Memorial Cancer Hospital, Lahore Pakistan
  • Aamna Hassan Department of Nuclear Medicine, Shaukat Khanam Memorial Cancer Hospital, Lahore Pakistan

DOI:

https://doi.org/10.51253/pafmj.v76iSUPPL-7.12592

Keywords:

Pulmonary blastoma, Pleuropulmonary blastoma, Fetal adenocarcinoma, Immunohistochemistry and biopsy, resectability, Chemotherapy.

Abstract

A case study of a 41-year-old male patient, a known smoker presented with complaints of right-sided chest pain, cough and shortness of breath for two months for which he got a chest X-ray, which revealed soft tissue opacity in the right upper and middle lobe. On examination there were slightly diminished breath sounds over the right hemi thorax. A pulmonary blastoma (PB) diagnosis was confirmed through a biopsy and immunohistochemistry. Diagnostic imaging (CT, MRI, PET-CT) was done as it plays a crucial part in seeing the tumor resectability, treatment response and rule out metastatic disease. Although surgical excision is the treatment of choice in PB but in our case, the tumor was extremely aggressive, progressive and irresectable so chemotherapy was recommended by a multidisciplinary specialized team. 

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References

1. Falco E, Vigani A, Francone E, Bonfante P, Bertie S, D’Ambra S. Adult pulmonary blastoma: report of an unusual malignant lung tumor. World J Clin Oncol 2014; 5(5): 1113-1116.

https://doi.org/10.5306/wjco.v5.i5.1113

2. Carrasco R, Blanco M, Otero D, Garcia-Fontan E. Classic biphasic pulmonary blastoma: importance of early treatment—a case report. Current Challenges in Thoracic Surg 2021; 3: 19:20-77.

https://doi.org/10.21037/ccts-20-77

3. Brambilla E, Travis WD, Colby TV, Corrin B, Shimosato. The new World Health Organization classification of lung tumours. Eur Respir J 2001; 18: 1059–1068.

https://doi.org/: 10.1183/09031936.01.00275301

4. Zhao YY, Liu L, Zhou T, Zhou NN, Yang YP, Hou X, et al. A retrospective analysis of the clinicopathological and molecular characteristics of pulmonary blastoma. Onco Targets Ther 2016 ; 9: 6915-6920.

https://doi.org/10.2147/OTT.S117097

5. Javed N, Ahmad AH, Khan AU, Ahmad I. Recurrent biphasic pulmonary blastoma in a young patient: a case report. Eur J Med Case Rep 2020; 4(1): 1-5.

https://doi.org/ 10.24911/ejmcr/173-1547876436

6. Parkhi M, Ahuja N, Kumar D, Basher RK, Singh N, Singh H, et al. Adult Pulmonary Blastoma: A Case Report with Spectrum of Rare Manifestations. Turk J Pathol 2024; 40(1): 63.

https://doi.org/10.5146/tjpath.2023.01597

7. Luo Z, Cao C, Xu N. Classic biphasic pulmonary blastoma: a case report and review of the literature. J Int Med Res 2020; 48(10): 300060520962394.

https://doi.org/10.1177/0300060520962394

8. Meng Z, Chen P, Zang F, Liu y, Xu X Chen Su, et al. A patient with classic biphasic pulmonary blastoma harboring CD74-ROS1 fusion responds to crizotinib. Onco Targets Ther 2018; 11: 157–161.

https://doi.org/10.2147/OTT.S150001

Published

15-07-2026

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Section

Case Reports

Categories

How to Cite

1.
Asghar A, Rauf MH, Sheikh AZ, Siddique K, Hassan A. Case Report of Adult Pulmonary Blastoma:  Very rare presentation. Pak Armed Forces Med J [Internet]. 2026 Jul. 15 [cited 2026 Jul. 22];76(SUPPL-7). Available from: https://www.pafmj.org/PAFMJ/article/view/12592