Comparison of the Efficacy of Infrared Heat Therapy with Cryotherapy as an Adjunct to Meglumine Antimoniate in the Treatment of Cutaneous Leishmaniasis

Zainab Kazam; Najia  Ahmed

doi:10.51253/pafmj.v76i5.12609

Authors

Zainab Kazam Department of Dermatology, Pak Emirates Military Hospital/National University of Medical Sciences (NUMS), Rawalpindi Pakistan
Najia Ahmed Department of Dermatology, Combined Military Hospital Quetta /National University of Medical Sciences (NUMS) Pakistan

DOI:

https://doi.org/10.51253/pafmj.v76i5.12609

Keywords:

Cutaneous Leishmaniasis; Cryotherapy; Meglumine Antimoniate; Leishmaniasis; Thermotherapy

Abstract

Objective: To compare the efficacy of infrared heat therapy with cryotherapy as an adjunct to Meglumine Antimoniate in the treatment of cutaneous leishmaniasis

Study Design: Quasi-experimental study

Place and duration of study: Combined Military Hospital, Quetta, Pakistan, from Jan to Jun 2024.

Methodology: Eligible participants were aged 18 years or older with confirmed cutaneous leishmaniasis. Participants were assigned to three treatment arms: cryotherapy with meglumine, meglumine alone, and infrared heat therapy with meglumine. The primary outcome was clinical cure after 2 months of therapy.

Results: The mean age of the participants was 28.6±9.2years. Most of the participants were male, comprising 87.5% of the patients. The duration of the disease among the participants was 3.6 months on average. On average, each participant had 4.7 lesions.

28 participants (87.5%)achieved a clinical cure in the group treated with cryotherapy and meglumine. 26 participants(81.2%)achieved a clinical cure in the group treated with infrared heat therapy and meglumine. Among those treated with meglumine alone,22 participants(68.7%)achieved a clinical cure. The p-value indicates a statistically significant difference in clinical cure rates among the treatment groups, with a value less than 0.05.

Conclusion: Combination therapy of meglumine with infrared heat and cryotherapy achieved better clinical cure when compared to meglumine alone.

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References

1. Corman HN, McNamara CW, Bakowski MA. Drug discovery for cutaneous leishmaniasis: a review of developments in the past 15 years. Microorganisms 2023; 11(12): 2845.

https://doi.org/10.3390/microorganisms11122845

2. Orabi MAA, Lahiq AA, Awadh AAA, Alshahrani MM, Abdel-Wahab BA, Abdel-Sattar ES. Alternative non-drug treatment options of the most neglected parasitic disease, cutaneous leishmaniasis: a narrative review. Trop Med Infect Dis 2023; 8(5): 275.

https://doi.org/10.3390/tropicalmed8050275

3. Lopez Y, Arana B, Rizzo N, Duran E, Acosta-Serrano Á, Mendizabal-Cabrera R. A neglected among the neglected: a review of cutaneous leishmaniasis in Guatemala. Trans R Soc Trop Med Hyg 2023; 117(9): 609-616. https://doi.org/10.1093/trstmh/trad024

4. Afonso RC, Yien RMK, de Siqueira LBO, Simas NK, Dos Santos Matos AP, Ricci-Júnior E. Promising natural products for the treatment of cutaneous leishmaniasis: a review of in vitro and in vivo studies. Exp Parasitol 2023; 251: 108554.

https://doi.org/10.1016/j.exppara.2023.108554

5. Linquest LA, Hickham LC, Richardson BJ, Hickham PR. Successful treatment of cutaneous leishmaniasis with cryotherapy. Cureus 2023; 15(7): e41871.

https://doi.org/10.7759/cureus.41871

6. Siadat AH, Iraji F, Zolfaghari A, Shariat S, Jazi SB. Heat therapy for cutaneous leishmaniasis: a literature review. J Res Med Sci 2021; 26: 15.

https://doi.org/10.4103/jrms.JRMS_934_19

7. Asilian A, Sadeghinia A, Faghihi G, Momeni A. Comparative study of the efficacy of combined cryotherapy and intralesional Meglumine Antimoniate (Glucantime) vs. cryotherapy and intralesional Meglumine Antimoniate (Glucantime) alone for the treatment of cutaneous leishmaniasis. Int J Dermatol 2004; 43(4): 281-283.

https://doi.org/10.1111/j.1365-4632.2004.02002.x

8. Junaid AJ. Treatment of cutaneous leishmaniasis with infrared heat. Int J Dermatol 1986; 25(7): 470-472.

https://doi.org/10.1111/j.1365-4362.1986.tb03460.x

9. López-Carvajal L, Cardona-Arias JA, Zapata-Cardona MI, Sánchez-Giraldo V, Vélez ID. Efficacy of cryotherapy for the treatment of cutaneous leishmaniasis: meta-analyses of clinical trials. BMC Infect Dis 2016; 16: 360. https://doi.org/10.1186/s12879-016-1663-1

10. Azim M, Khan SA, Ullah S, Ullah S, Anjum SI. Therapeutic advances in the topical treatment of cutaneous leishmaniasis: a review. PLoS Negl Trop Dis 2021; 15(3): e0009099.

https://doi.org/10.1371/journal.pntd.0009099

11. de Vries HJC, Schallig HD. Cutaneous leishmaniasis: a 2022 updated narrative review into diagnosis and management developments. Am J Clin Dermatol 2022; 23(6): 823-840.

https://doi.org/10.1007/s40257-022-00726-8

12. Sridharan K, Sivaramakrishnan G. Comparative assessment of interventions for treating cutaneous leishmaniasis: a network meta-analysis of randomized clinical trials. Acta Trop 2021; 220: 105944.

https://doi.org/10.1016/j.actatropica.2021.105944

13. Etemadifar A, Bahraminejad S, Pardakhty A, Sharifi I, Keyhani A, Ranjbar M. Preparation, characterization, and leishmanicidal assessment of silver- and dapsone-loaded niosomes co-administration: in silico and in vitro study. Adv Pharm Bull 2024; 14(4): 892-907.

https://doi.org/10.34172/apb.42740.

14. Alidosti M, Heidari Z, Shahnazi H, Zamani-Alavijeh F. Behaviors and perceptions related to cutaneous leishmaniasis in endemic areas of the world: a review. Acta Trop 2021; 223: 106090.

https://doi.org/10.1016/j.actatropica.2021.106090

15. Zabala-Peñafiel A, Todd D, Daneshvar H, Burchmore R. The potential of live attenuated vaccines against Cutaneous Leishmaniasis. Exp Parasitol 2020;210:107849. https://doi.org/10.1016/j.exppara.2020.107849

16. eBioMedicine. Leishmania: an urgent need for new treatments. EBioMedicine 2023; 87: 104440.

https://doi.org/10.1016/j.ebiom.2023.104440

17. Jyotisha, Qureshi R, Qureshi IA. Development of a multi-epitope vaccine candidate for leishmanial parasites applying immunoinformatics and in vitro approaches. Front Immunol 2023; 14: 1269774.

https://doi.org/10.3389/fimmu.2023.1269774

18. Alunda JM. Antileishmanial and antitrypanosomal drugs for the current century. Microorganisms 2023; 12(1): 43.

https://doi.org/10.3390/microorganisms12010043