Quantification of Inflammation Following Neodymium Yttrium Aluminum Garnet (Nd:YAG) Laser Capsulotomy and Assessing the Anti-Inflammatory Effects of Nepafenac 0.1 % & Pred Forte 1%

Atiya Iqbal; Waqar Muzaffar; Saquib Naeem; Jawwad  Ahmad; Shagufta  Parveen; Raheela Hafiz

doi:10.51253/pafmj.v76i4.13242

Authors

Atiya Iqbal Department of Ophthalmology, Armed Forces Institute of Ophthalmology/National University of Medical Sciences (NUMS), Rawalpindi Pakistan
Waqar Muzaffar Department of Ophthalmology, Armed Forces Institute of Ophthalmology/National University of Medical Sciences (NUMS), Rawalpindi Pakistan
Saquib Naeem Department of Ophthalmology, Armed Forces Institute of Ophthalmology/National University of Medical Sciences (NUMS), Rawalpindi Pakistan
Jawwad Ahmad Department of Ophthalmology, Armed Forces Institute of Ophthalmology/National University of Medical Sciences (NUMS), Rawalpindi Pakistan
Shagufta Parveen NUMS RawalpindiDepartment of Ophthalmology, Armed Forces Institute of Ophthalmology/National University of Medical Sciences (NUMS), Rawalpindi Pakistan
Raheela Hafiz Department of Ophthalmology, Armed Forces Institute of Ophthalmology/National University of Medical Sciences (NUMS), Rawalpindi Pakistan

DOI:

https://doi.org/10.51253/pafmj.v76i4.13242

Keywords:

Cataract Extraction, Capsule Opacification, Capsulotomy, Posterior Capsular Opacification, YAG Capsulotomy, Inflammation.

Abstract

Objectives: To quantify intraocular inflammation following Nd:YAG Laser capsulotomy and compare the effectiveness of topical non-steroidal and steroidal anti-inflammatory medication to reduce post-capsulotomy inflammation.

Study Design: Quasi-experimental study.

Place and Duration of Study: Armed Forces Institute of Ophthalmology, Rawalpindi Pakistan, from Jan to Jun 2023.

Methodology: The patients were divided into two groups, on the basis of topical medication prescribed as per ophthalmologist’s discretion. Group-A was administered topical steroid drug (Pred Forte eye drops, Prednisolone Acetate 1%) and Group-B was administered non-steroidal anti-inflammatory drug (Nepac eye drops, Nepafenac 0.1%). Following Nd: YAG laser treatment, every patient was examined at 2 hours, 1 week, and 2 weeks to assess best corrected visual acuity, intraocular pressure and central macular thickness.

Results: There were 94 patients (47 in each group) with mean age of 52.1±7.3 years. There were 46(48.9%) males and 48(51.1%) females. Best corrected visual acuity was found to improve following Nd:YAG in all the patients. The inflammation was found to rise acutely after procedure and gradually decreased till 2 weeks post-procedure. The optical parameters were found to rise slightly after procedure but were self-limiting in nature. Non-steroidal anti-inflammatory drug was found to be more effective in preventing the ocular inflammation as compared to steroid drug.

Conclusion: The topical nonsteroidal anti-inflammatory drugs were found to be slightly better at lowering post-capsulotomy inflammation compared to topical steroids. This suggests NSAIDS as a viable treatment option for post-capsulotomy intraocular inflammation.

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