The prevalence of lymph node metastasis in clinically negative neck (CNo) in Oral squamous cell carcinoma patients.

Authors

  • Tariq Mahmood Department of Oral & Maxillofacial Surgery, Armed Forces Institute of Dentistry, Rawalpindi/National University of Medical Sciences (NUMS) Pakistan
  • Shafiullah Khan Department of Oral & Maxillofacial Surgery, Armed Forces Institute of Dentistry, Rawalpindi/National University of Medical Sciences (NUMS) Pakistan
  • Adnan Babar Department of Oral & Maxillofacial Surgery, Armed Forces Institute of Dentistry, Rawalpindi/National University of Medical Sciences (NUMS) Pakistan
  • Shahid Iqbal Khan Department of Oral & Maxillofacial Surgery, Armed Forces Institute of Dentistry, Rawalpindi/National University of Medical Sciences (NUMS) Pakistan
  • Muhammad Junaid Department of Oral & Maxillofacial Surgery, Armed Forces Institute of Dentistry, Rawalpindi/National University of Medical Sciences (NUMS) Pakistan
  • Ashar Waheed Department of Oral & Maxillofacial Surgery, Armed Forces Institute of Dentistry, Rawalpindi/National University of Medical Sciences (NUMS) Pakistan

DOI:

https://doi.org/10.51253/pafmj.v76iSUPPL-1.13451

Keywords:

Cervical metastasis, Elective neck dissections, Neck dissections, Occult metastasis, Oral cancer, Oral Squamous cell carcinoma.

Abstract

Objective: This study aims to assess the prevalence of cervical lymph node metastasis in Oral squamous cell carcinoma patients with clinically negative necks.

Study design: A prospective cross-sectional study.

Place and Duration of study: Armed Forces Institute of Dentistry, Rawalpindi, one year (i-e) 1st Jan 2024 to 31st Dec 2024)

Methodology:  A total of 50 (n=50) biopsy-proven oral squamous cell carcinoma patients with clinically negative necks, who had undergone Tumor resection along with elective neck dissections. Their post-operative histopathology reports were analyzed to assess cervical metastasis after applying inclusion and exclusion criteria of the study. Data was collected, entered, and analyzed through SPSS version 26.

Results: out of 50 patients (n=50), 16(32%) patients had histopathologically confirmed cervical metastasis despite  CNo status. The frequency of cervical metastasis was reported in 32% of total patients selected for study. The highest frequency of metastasis was observed in buccal mucosa tumors 8 (50%) out of 16 patients, Alveolus 6 (37.5%) out 16 patients followed by tongue 2 (12.5%) out 16 patients who had metastasis. No cervical metastasis was recorded for lip tumors.

Conclusion: Overall higher prevalence was recorded in Oral Squamous cell carcinoma with clinically negative necks, which necessitates Elective Neck Dissections in high risk sites of oral cavity like buccal mucosa, Alveolus & tongue even with clinically negative necks.

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References

1. Tan Y, Wang Z, Xu M, Li B, Huang Z, Qin S, et al. Oral squamous cell carcinomas: state of the field and emerging directions. Int J Oral Sci 2023; 15(1): 44.

https://doi.org/10.1038/s41368-023-00249-w

2. Ikram A, Pervez S, Khadim MT, Sohaib M, Uddin H, Badar F, et al. National cancer registry of Pakistan: first comprehensive report of cancer statistics 2015–2019. J Coll Physicians Surg Pak 2023; 33(6): 625-632. https://doi.org/10.29271/jcpsp.2023.06.625

3. Zahid KS, Hidayat W, Zakiawati D. Viral involvement in oral potentially malignant disorder: a scoping review. Cancer Manag Res 2025; 17: 309-330. https://doi.org/10.2147/cmar.s485418

4. Struckmeier AK, Buchbender M, Moest T, Lutz R, Agaimy A, Kesting M et al. Occult metastasis is no burden factor in oral squamous cell carcinoma patients when adhering to a standardized approach in neck dissection. Clin Oral Investig 2024; 28(1): 113. https://doi.org/10.1007/s00784-024-05514-8

5. Zainal FR, Abdul Rahman ZA, Daniel Lim KH, Chan SS, Tan CC. Prevalence of occult cervical lymph nodes metastasis in cN0 oral squamous cell carcinoma (OSCC). J Stomatol Oral Maxillofac Surg 2025; 126(2): 102070.

https://doi.org/10.1016/j.jormas.2024.102070

6. Takamura M, Nikkuni Y, Hayashi T, Katsura K, Nishiyama H, Yamazaki M, et al. Comparing the diagnostic accuracy of ultrasonography, CT, MRI, and PET/CT in cervical lymph node metastasis of oral squamous cell carcinoma. Biomedicines 2023; 11(12): 3119. https://doi.org/10.3390/biomedicines11123119

7. Warnakulasuriya S. Epidemiology of oral cancer in South and South‐East Asia: incidence and mortality. Oral Dis 2024; 30(8): 4847-4854. https://doi.org/10.1111/odi.14906

8. Fatima J, Fatima E, Mehmood F, Ishtiaq I, Khan MA, Khurshid HMS, et al. Comprehensive analysis of oral squamous cell carcinomas: clinical, epidemiological, and histopathological insights with a focus on prognostic factors and survival time. Cureus 2024; 16(2): e54394.

https://doi.org/10.7759/cureus.54394

9. Al-Jamaei A, Van Dijk B, Helder M, Forouzanfar T, Leemans C, De Visscher J. A population-based study of the epidemiology of oral squamous cell carcinoma in the Netherlands 1989–2018, with emphasis on young adults. Int J Oral Maxillofac Surg 2022; 51(1): 18-26. https://doi.org/10.1016/j.ijom.2021.03.006

10. Hashmi AA, Mudassir G, Rashid K, Malik UA, Zia S, Zia F, et al. Risk factors of oral squamous cell carcinoma with special emphasis on areca nut usage and its association with clinicopathological parameters and recurrence. Int J Surg Oncol 2024; 2024: 9725822. https://doi.org/10.1155/2024/9725822

11. Farrokhian N, Holcomb AJ, Dimon EL, Karadaghy OA, Ward CM, Whiteford E, et al. Development and validation of machine learning models for predicting occult nodal metastasis in early-stage oral cavity squamous cell carcinoma. JAMA Netw Open 2022; 5(4): e227226.

https://doi.org/10.1001/jamanetworkopen.2022.7226

12. Bittar RF, Ferraro HP, Ribas MH, Lehn CN. Predictive factors of occult neck metastasis in patients with oral squamous cell carcinoma. Braz J Otorhinolaryngol 2016; 82(5): 543-547.

https://doi.org/10.1016/j.bjorl.2015.09.005

13. Cell OS. Management of the Neck in Oral Squamous Cell. The Head and Neck Cancer Patient: Neoplasm Management, An Issue of Oral and Maxillofacial Surgery Clinics of North America. 2018; 31(1): 69.

14. Lin NC, Hsu JT, Tsai KY. Difference between female and male patients with oral squamous cell carcinoma: a single-center retrospective study in Taiwan. Int J Environ Res Public Health 2020; 17(11): 3978.

https://doi.org/10.3390/ijerph17113978

15. Thoenissen P, Heselich A, Deeg S, Al-Maawi S, Tanneberger A, Sader R, et al. Extent of neck dissection and cervical lymph node involvement in oral squamous cell carcinoma. Front Oncol 2022; 12: 812864. https://doi.org/10.3389/fonc.2022.812864

16. Haseeb AA, Rahim AU, Iqbal S, Batool H, Younas S, Manzoor HJ. The frequency of occult cervical metastasis in oral squamous cell carcinoma patients: a cross-sectional study. J Pak Med Assoc 2022; 72(1): 66-70. https://doi.org/10.47391/jpma.1512

17. Yamagata K, Fukuzawa S, Noguchi A, Takaoka S, Uchida F, Ishibashi-Kanno N, et al. Predictors of occult metastasis and prognostic factors in patients with cN0 oral cancer who underwent elective neck dissection. Diseases 2024; 12(2): 39.

https://doi.org/10.3390/diseases12020039

18. Mehta N, Jakhetiya A, Patel D, Pandey A, Patel T, Patidar N, et al. Prevalence and patterns of nodal metastasis among oral cavity cancer patients: a prospective observational study. J Maxillofac Oral Surg 2023; 22(1): 245-251.

https://doi.org/10.1007/s12663-022-01739-w

19. Almangush A, Mäkitie AA, Triantafyllou A, de Bree R, Strojan P, Rinaldo A, et al. Staging and grading of oral squamous cell carcinoma: an update. Oral Oncol 2020; 107: 104799.

https://doi.org/10.1016/j.oraloncology.2020.104799

20. Emmanuel A, Das SN, Rath R, Nayak M, Selvamani B, Behera S et al. Prognostic significance of anatomic site-specific depth of invasion in oral squamous cell carcinoma: an eastern Indian multi-center study. Ann Diagn Pathol 2024; 73: 152374.

https://doi.org/10.1016/j.anndiagpath.2024.152374

21. Mermod M, Jourdan EF, Gupta R, Bongiovanni M, Tolstonog G, Simon C, et al. Development and validation of a multivariable prediction model for the identification of occult lymph node metastasis in oral squamous cell carcinoma. Head Neck 2020; 42(8): 1811-1820. https://doi.org/10.1002/hed.26105

22. Koyfman SA, Ismaila N, Crook D, D'Cruz A, Rodriguez CP, Sher DJ, et al. Management of the neck in squamous cell carcinoma of the oral cavity and oropharynx: ASCO clinical practice guideline. J Clin Oncol 2019; 37(20): 1753-1774.

https://doi.org/10.1200/jco.18.01921

23. Vassiliou LV, Acero J, Gulati A, Hölzle F, Hutchison IL, Prabhu S, et al. Management of the clinically N0 neck in early-stage oral squamous cell carcinoma (OSCC): an EACMFS position paper. J Craniomaxillofac Surg 2020; 48(8): 711-718.

https://doi.org/10.1016/j.jcms.2020.06.004

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Published

30-01-2026

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How to Cite

1.
Mahmood T, Khan S, Babar A, Khan SI, Junaid M, Waheed A. The prevalence of lymph node metastasis in clinically negative neck (CNo) in Oral squamous cell carcinoma patients. Pak Armed Forces Med J [Internet]. 2026 Jan. 30 [cited 2026 Feb. 6];76(SUPPL-1):S197-S201. Available from: https://www.pafmj.org/PAFMJ/article/view/13451