Prognostic Value of Pentraxin-3 and Procalcitonin in Neonatal Sepsis

Mudassar  Rubab; Sumbul  Nida; Amina  Tariq; Hina  Batool

doi:10.51253/pafmj.v76iSUPPL-9.13768

Authors

Mudassar Rubab Department of Pathology, Pakistan Aeronautical Complex Hospital, Kamra Attock Pakistan
Sumbul Nida Department of Pathology, Pakistan Aeronautical Complex Hospital, Kamra Attock Pakistan
Amina Tariq Department of Pathology, Pakistan Aeronautical Complex Hospital, Kamra Attock Pakistan
Hina Batool Department of Paediatrics, Pakistan Aeronautical Complex Hospital, Kamra Attock Pakistan

DOI:

https://doi.org/10.51253/pafmj.v76iSUPPL-9.13768

Keywords:

Neonatal Sepsis, Pentraxin-3, Procalcitonin, Sequential Organ Failure Assessment.

Abstract

Objective: To evaluate the prognostic value of Pentraxin-3 and Procalcitonin in neonatal sepsis.

Study Design: Prospective observational study.

Place and Duration of Study: Neonatal Intensive Care Unit, Pakistan Aeronautical Complex Hospital, Kamra, Attock, Pakistan, from May 24 to May 25.

Methodology: A total of seventy neonates with sepsis were enrolled, including forty in the improved group and thirty in the deteriorated group. Clinical evaluation included anthropometric assessment, detailed history, physical examination, and disease progression scoring using the neonatal 0053equential Organ Failure Assessment. Laboratory parameters included complete blood count, blood culture, high-sensitivity C-reactive protein, Procalcitonin, and Pentraxin-3 levels.

Results: At baseline, median Pentraxin-3 levels was comparable between groups (1155.00 vs. 1006.50 pg/mL), while median levels of procalcitonin (1.58 vs. 5.80 ng/mL), hs-CRP (44.50 vs. 88.50 mg/L), and creatinine (71.50 vs. 195.00 µmol/L) were significantly higher in the deteriorated group (p<0.001). After 72 hours, the improved group showed reductions in median nSOFA score (8→5), Pentraxin-3 (1155.00 →327.00 pg/mL), procalcitonin (1.58→0.50 ng/mL), hs-CRP (44.50→7.90 mg/L), TLC (14.95→8.00×10⁹/L), and creatinine (71.50 →55.50 µmol/L) (all p<0.05). Values before and after the arrows represent baseline and 72-hour measurements, respectively. The deteriorated group demonstrated increases in nSOFA (10→18), Pentraxin-3 (1006.5→2394.5 pg/mL), procalcitonin (5.80→14.75 ng/mL), hs-CRP (88.5→217 mg/L), and TLC (18.4→23.4×10⁹/L) (all p<0.05). Both markers showed strong correlation with worsening neonatal Sequential Organ Failure Assessment scores and adverse outcomes.

Conclusion: Procalcitonin and Pentraxin-3 are valuable prognostic indicators in neonatal sepsis. Their incorporation into clinical practice may enhance early risk stratification, guide treatment decisions, and improve neonatal outcomes.

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