Comparison of Intrauterine versus Per-Rectal Misoprostol in Prevention of Postpartum Hemorrhage in Women undergoing Caesarean Section: A Quasi-Experimental Study

Zara Gul; Gulfreen Waheed

doi:10.51253/pafmj.v76iSUPPL-1.13846

Authors

Zara Gul Department of Obstetrics & Gynecology, Avicenna Hospital, Lahore Pakistan
Gulfreen Waheed Department of Obstetrics & Gynecology, Avicenna Hospital, Lahore Pakistan

DOI:

https://doi.org/10.51253/pafmj.v76iSUPPL-1.13846

Keywords:

Caesarean Section, Misoprostol, Postpartum Hemorrhage, Uterotonic

Abstract

Objective: to compare the efficacy of the intrauterine vs. Rectal Misoprostol in preventing PPH among women undergoing caesarean section.

Study Design: Quasi-experimental study.

Place and Duration of Study: Department of Gynecology and Obstetrics, Avicenna Hospital, Lahore Pakistan, from May to Oct 2023.

Methodology: Participants were allocated into two groups: Group A received 800 μg intrauterine misoprostol, while Group B received 800 μg rectal misoprostol immediately after delivery. The primary outcome was the occurrence of PPH. Secondary outcomes included approximate blood loss, hospital stay, maternal complications, adverse effects, and additional uterotonic requirement.

Results: The intrauterine group showed significantly lower mean blood loss (370.94±120.14 mL) compared to the rectal group (500.32±140.86 mL, p<0.001). The PPH incident was clearly reduced (13.1% vs. 52.0%, p<0.001). The stay in the hospital was reduced in the intrauterine group (2.23(0.63) days vs. 3.14(0.85) days, p<0.001). Fewer women require additional uterotonic (10.7% vs. 39.8%, p<0.001). The adverse effects were less frequent in the intrauterine group.

Conclusions: The intrauterine misoprostol is better than rectal misoprostol during the Caesarean section with low complications

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