Association of The Uric Acid-To-High-Density Lipoprotein Cholesterol Ratio with Coronary Artery Disease in Patients Younger Than 45 Years Presenting with Stable Chest Pain

Athar Sajjad; Azhar Ali Chaudhary; Usman Iqbal; Iftikhar Ahmed; Junaid Arshad; Sanaullah Khan

doi:10.51253/pafmj.v76iSUPPL-9.14094

Authors

Athar Sajjad Department of Cardiology, Armed Forces Institute of Cardiology/National Institute of Heart Diseases/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Azhar Ali Chaudhary Department of Cardiology, Armed Forces Institute of Cardiology/National Institute of Heart Diseases/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Usman Iqbal Department of Cardiology, Armed Forces Institute of Cardiology/National Institute of Heart Diseases/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Iftikhar Ahmed Department of Cardiology, Armed Forces Institute of Cardiology/National Institute of Heart Diseases/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Junaid Arshad Department of Cardiology, Armed Forces Institute of Cardiology/National Institute of Heart Diseases/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Sanaullah Khan Department of Cardiology, Armed Forces Institute of Cardiology/National Institute of Heart Diseases/National University of Medical Sciences (NUMS) Rawalpindi Pakistan

DOI:

https://doi.org/10.51253/pafmj.v76iSUPPL-9.14094

Keywords:

Coronary Artery Disease, Uric Acid to HDL Ratio, Younger Patients

Abstract

Objective: To investigate the frequency of coronary artery disease in patients younger than 45 years presenting with stable chest pain and then to compare the uric acid to HDL ratio in patients with and without coronary artery disease.

Study Design: Cross-sectional survey.

Place and Duration of Study: Armed Forces Institute of Cardiology & National Institute of Heart Diseases, Rawalpindi, Pakistan, from Jul to Nov 2025.

Methodology: After meeting the selection criteria, a total of 200 patients were enrolled. Patients underwent coronary angiography. Based on the findings, they were categorized into two groups: with coronary artery disease or without coronary artery disease. The angiographic procedure was performed by a single team of cardiologists with assistance from the researcher, under local anesthesia. Blood samples were collected using a 3 cc disposable syringe to assess the uric acid-to-HDL ratio.

Results: In this study, 143(71.5%) were male, 163(81.5%) were hypertensive, and 75(37.5%) were diabetic. Regarding the outcome variable, CAD was detected in 125(62.5%) patients. The median uric acid to HDL ratio was 0.34 (IQR: 0.16) in patients with CAD, compared to 0.08 (IQR: 0.03) in those without CAD (p<0.001).

Conclusion: It can be concluded that the frequency of coronary artery disease was 62.5% among patients younger than 45 years presenting with stable chest pain, and the uric acid to HDL ratio showed a significant association with coronary artery disease.

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