Early Pregnancy Failure in Patients with Thyroid Disease
DOI:
https://doi.org/10.51253/pafmj.v76iSUPPL-9.14116Keywords:
Abortion, Bogy Mass Index, Early Pregnancy loss, Hypertension, Thyroid diseasesAbstract
Objective: To assess the risk of pregnancy failure by studying the relation between thyroid profile and rate of abortion.
Study Design: Quasi-experimental study
Place and Duration of Study: Department of Gynaecology and Obstetrics, Pak Emirates Military Hospital Rawalpindi, Pakistan from Jan to Jul 2024.
Methodology: This study included 255 women between six and twelve weeks gestation having a single pregnancy. They were divided into three equal groups: the first with healthy pregnancies and no history of miscarriage, the second with at least one prior miscarriage, and the third with complaints of vaginal bleeding in early pregnancy. Women with unclear dates or pre-existing conditions like diabetes, hypertension, thyroid disease, kidney or liver issues, autoimmune disorders, or multiple pregnancies were excluded to maintain clear study criteria.
Results: The women had a mean age of 31.68±7.39 years and BMI of 27.26±6.29, with no significant differences in age (p = 0.475) or BMI (p = 0.924) across the groups. Hemoglobin levels differed significantly (p = 0.040), being higher in the healthy group, while VDRL positivity varied (p = 0.008) and was highest in the bleeding group at 5.9%. T4 was highest in the healthy group (121.85±15.74 nmol/L, p < 0.001) and TSH was highest in the miscarriage group (2.06±0.33 mIU/L, p < 0.001). T3 and T4 showed a significant negative correlation with TSH.
Conclusion: The study suggests that differences in hemoglobin, infection markers, and thyroid hormones may influence early pregnancy complications in women with prior miscarriages or early pregnancy bleeding.
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Copyright (c) 2026 Noreen Aslam, Tehreem Yazdani, Afeera Afsheen, Salma Nisar, Rabia Habib, Faryal Sabir
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