ARSENIC INDUCED HISTOMORPHOLOGICAL ALGTERATIONS IN SIZE OF HEPATIC LOBULE AND AMELIORATIVE EFFECTS OF LAGENARIA SICERARIA

Authors

  • Saima Qureshi Army Medical College/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Umbreen Noor Riyadh Elm University, Riyadh KSA
  • Ayesha Baqar Watim Dental College & Hospital Islamabad Pakistan
  • Khadija Qamar Army Medical College/National University of Medical Sciences (NUMS) Rawalpindi Pakistan,

Keywords:

Sprague dawley, Lagenaria siceraria, Sodium arsenite

Abstract

Objective: To study the effects of Lagenaria siceraria and arsenic on size of Hepatic lobule of Sprague Dawley rat. Study Design: Laboratory-based randomized controlled trial. Place and Duration of Study: Army Medical College, Rawalpindi, and National Institute of Health (NIH), Islamabad, for eight weeks, from 20th Mar 2017 to 14th May 2017.
Material and Methods: Fifty Sprague Dawley rats both male and female selected randomly and broadly allocated into five groups, each with 10 animals. Groups A and B animals were controls, C, D and E served as experimental groups. Sodium arsenite 5mg/kg body weight was initially given for a period of 4 weeks to the experimental groups C, D and E. After 4 weeks of therapy, the animals of groups A and C were sacrificed for histopathological study of liver to see the immediate effects of arsenic. Within the next 4 weeks group D animals were retained without any intervension. Group E animals were administered sodium arsenite (5mg/kg body weight) along with Lagenaria siceraria at a dose of 100mg/kg bodyweight. Group B served as a control for experimental group D and E. Animals of group B, D and E were sacrificed after last dose at the end these 4 weeks. Liver was removed and prepared for histological study. Size of hepatic lobule was studied. Data were analysed by SPSS V 22. A p-value 0.05 was considered statistically significant. Results: Moderate increase in the size of hepatic lobule was seen in group C as compared to control group A. Group.....

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Published

28-02-2019

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Original Articles

How to Cite

1.
Qureshi S, Noor U, Baqar A, Qamar K. ARSENIC INDUCED HISTOMORPHOLOGICAL ALGTERATIONS IN SIZE OF HEPATIC LOBULE AND AMELIORATIVE EFFECTS OF LAGENARIA SICERARIA. Pak Armed Forces Med J [Internet]. 2019 Feb. 28 [cited 2024 Jun. 18];69(1):76-82. Available from: https://www.pafmj.org/PAFMJ/article/view/2500