Therapeutic Effects of Probiotics In The Reduction of Neonatal Hyperbilirubinemia
DOI:
https://doi.org/10.51253/pafmj.v74i1.3071Keywords:
Hyperbilirubinemia, Neonatal jaundice, Limosilactobacillus reuteri, InfantAbstract
Objective: To evaluate probiotics' effects in reducing hyperbilirubinemia in late preterm and term neonates.
Study Design: Quasi-experimental study
Place and Duration of Study: Department of Neonatology, Pakistan Institute of Medical Sciences (PIMS), Islamabad Pakistan, from Oct 2018 to Mar 2019.
Methodology: The quasi-experimental study was conducted on 60 neonates with hyperbilirubinemia. They were randomly
divided into two Groups. Group-A (n=30) received phototherapy. Group-B (n=30) received probiotics containing
Lactobacillus reuteri at a dose of 5 drops daily for three days, in addition to phototherapy. Total serum bilirubin was
calculated at 0, 24 and 72 hours for both Groups.
Results: In Group-A, the mean total bilirubin in mg/dl at 0, 24 and 72 hours were 18.14±2.35, 15.28±2.93 and 12.31±2.29,
respectively. Similarly, in Group-B, it was 19.86±5.85, 16.23±4.01 and 10.75±2.23 at 0, 24 and 72 hours, respectively. There was an insignificant statistical difference in mean total bilirubin between Groups A and B at 0 and 24 hours (p<0.001). However, when comparison was made at 72 hours, a significant statistical difference was observed in Group-B (Intervention Group) (p=0.005)
Conclusion: Probiotics significantly lowered total serum bilirubin in neonates with hyperbilirubinemia. Further studies are
required to evaluate its role in physiological and pathological jaundice.
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