COMPARISON OF TOPICAL USE OF PROTAMINE AND TRANEXAMIC ACID IN SURGICAL PATIENTS REQUIRING CARDIO-PULMONARY BYPASS

Protamine and Tranexamic Acid in Cardio-Pulmonary Bypass

Authors

  • Musfireh Siddiqeh Armed Forces Institute of Cardiology/National Institute of Heart Diseases Rawalpindi
  • Rashad Siddiqi Armed Forces Institute of Cardiology/National Institute of Heart Diseases Rawalpindi
  • Nasir Ali Armed Forces Institute of Cardiology/National Institute of Heart Diseases Rawalpindi
  • Afsheen Iqbal Armed Forces Institute of Cardiology/National Institute of Heart Diseases Rawalpindi
  • Zilfah Younus Armed Forces Institute of Cardiology/National Institute of Heart Diseases Rawalpindi
  • Intisar Ul Haq Armed Forces Institute of Cardiology/National Institute of Heart Diseases Rawalpindi

Keywords:

Cardiac surgery, Protamine, Tranexamic acid, Post-operative blood loss

Abstract

Objective: To determine the effectiveness of local protamine in reducing post-operative blood loss compared to local tranexamic acid.

Study Design: Randomized controlled trial.

Place and Duration of Study: Armed Forces Institute of Cardiology/National Institute of Heart Diseases Rawalpindi from January 2011 to September 2011.

Patients and Methods: One hundred and twenty cardiac surgical patients were randomly divided into two equal groups, one receiving local protamine while the other group receiving local tranexamic acid before chest closure. The efficiency was measured as post-operative blood loss and requirement of blood and blood products in the post-surgical ICU.

Results: Average blood loss in protamine group was significantly less (252.97 ml) compared to tranexamic acid group (680.67 ml). Number of patients requiring no post-operative blood transfusion was significantly higher in protamine group (76.7%) compared to tranexamic acid group (53.3%).

Conclusion:  Local protamine is more effective in reducing post-operative blood loss than local tranexamic acid.

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Published

28-02-2015

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Original Articles

How to Cite

1.
Siddiqeh M, Siddiqi R, Ali N, Iqbal A, Younus Z, Haq IU. COMPARISON OF TOPICAL USE OF PROTAMINE AND TRANEXAMIC ACID IN SURGICAL PATIENTS REQUIRING CARDIO-PULMONARY BYPASS: Protamine and Tranexamic Acid in Cardio-Pulmonary Bypass. Pak Armed Forces Med J [Internet]. 2015 Feb. 28 [cited 2024 Nov. 2];65(1):31-5. Available from: https://www.pafmj.org/PAFMJ/article/view/651