DIACEREIN: A TREATMENT OPTION IN PAINFUL PRIMARY KNEE

Diacerein in Knee Steoarthritis

Authors

  • Noreen Akhter Armed Forces Institute of Rehabilitation Medicine Rawalpindi
  • Atif Ahmed Khan Armed Forces Institute of Rehabilitation Medicine Rawalpindi
  • Saeed Bin Ayaz Armed Forces Institute of Rehabilitation Medicine Rawalpindi
  • Syed Mohammad Hassan Akhter Engineering Centre Risalpur
  • Aamir l Afza College of Physicians and Surgeons Pakistan (CPSP) Islamabad

Keywords:

American College of Rheumatology criteria, Knee Osteoarthritis (KOA), Kellgren-Lawrence Radiological Classification for Knee Osteoarthritis, Visual Analog Scale (VAS), Diacerein

Abstract

Objective: To identify the efficacy and side effects of Diacerein in patients with mild to moderate knee osteoarthritis.

Study Design: Quasi experimental study.

Place and Duration of Study: Outpatient Department of Armed Forces Institute of Rehabilitation Medicine, Rawalpindi from June 2012 to June 2013.

Material and Methods: Ninety cases fulfilling American College of Rheumatology criteria for diagnosis of Knee Osteoarthritis and falling in Grades I→III of Kellgren-Lawrence Radiological Classification for Knee Osteoarthritis were included. Pre-treatment associated symptoms, complete blood count, renal and liver function tests were documented.  After a baseline pain assessment on a 10-Point Visual Analogue Scale, 50 mg of Diacerein was given orally for 4 months followed by pain assessment and inquiry about adverse effects at 6th week, 3rd and 6th months. Post-treatment labs were repeated. Reduction in pain was analyzed by paired-sample t-test using SPSS version 17. Chi-Square test was used to assess the frequency of adverse effects. A p-value < 0.05 was considered significant.

Results: Mean age was 61.5 ± 7.8 years. Majority 77 (85.6%) were females. Mean Visual Analogue Scale at start was 6.1 ± 0.87. Significant pain reduction measured on Visual Analogue Scale was observed at six weeks (4.6 ± 1.2) (p < 0.001), three months (2.37 ± 0.91) (p < 0.001) and six months (2.2 ± 0.85) (p < 0.001). Very few patients developed diarrhea 3.3% and nausea 4.4%.

Conclusion: Diacerein is effective drug with minimal side effects for treatment of mild to moderate painful Knee Osteoarthritis

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Published

28-02-2015

Issue

Section

Original Articles

How to Cite

1.
Akhter N, Khan AA, Ayaz SB, Akhter SMH, Afza A l. DIACEREIN: A TREATMENT OPTION IN PAINFUL PRIMARY KNEE: Diacerein in Knee Steoarthritis. Pak Armed Forces Med J [Internet]. 2015 Feb. 28 [cited 2024 Nov. 2];65(1):77-80. Available from: https://www.pafmj.org/PAFMJ/article/view/678