Paediatric Patients-Based Case-Control Analysis: The Association Between Serum Vitamin D Levels And Febrile Seizures
DOI:
https://doi.org/10.51253/pafmj.v74i2.6801Keywords:
Febrile seizures, hypovitaminosis, paediatric population, vitamin DAbstract
Objective: To determine the association between serum vitamin D levels and febrile seizures in the paediatric patients.
Study Design: Case-Control Study.
Place and Duration of Study: Abbasi Shaheed Hospital, Karachi Pakistan, from Mar 2020 to Mar 2021.
Methodology: The study included all pyrexia paediatric patients, both with and without febrile seizures, as cases and controls. Children aged below six months or older than 60 months, with a previous history of afebrile seizures, diagnosed with central nervous system infection, dehydration, or electrolyte disturbance, were excluded from the study. Serum vitamin D levels and other demographic data were documented.
Results: The study included 86 cases and controls. The mean age of cases was 28.07±16.47, and the controls were 26.38±15.72 months. The rate of vitamin D insufficiency was three times more likely in cases compared to controls, i.e. [OR, 95% CI: 3.95 (2.084—7.489)] with p=0.0001.
Conclusion: Vitamin D deficiency is substantially more likely in the case than in the control group. As a result, children with febrile seizures should have their serum vitamin D levels tested.
Downloads
References
Natsume J, Hamano SI, Iyoda K, Kanemura H, Kubota M,
Mimaki M, et al. New guidelines for management of febrile
seizures in Japan. Brain Dev 2017; 39(1): 2-9.
https://doi.org/10.1016/j.braindev.2016.06.003
Habib Z, Akram S, Ibrahim S, Hassan B. Febrile seizures: factors
affecting risk of recurrence in Pakistani children presenting at
The Aga Khan University Hospital. J Pak Med Assoc 2003; 53(1):
-17.
Al Morshedy S, Elsaadany HF, Ibrahim HE, Sherif AM, Farghaly
MA, Allah MA, et al. Interleukin-1β and interleukin-1receptor
antagonist polymorphisms in Egyptian children with febrile
seizures: a case-control study. Medicine 2017; 96(11): 1-6.
https://doi.org/10.1097/md.0000000000006370
Kumar N, Midha T, Rao YK. Risk factors of recurrence of febrile
seizures in children in a tertiary care hospital in Kanpur: a one
year follow up study. Ann Indian Acad Neurol 2019; 22(1): 31-
https://doi.org/10.4103/aian.aian_472_17
Renda R, Yüksel D, Gürer YY. Evaluation of patients with febrile
seizure: risk factors, reccurence, treatment and prognosis.
Pediatr Emerg Care 2020; 36(4): 173-177.
https://doi.org/10.1097/pec.0000000000001173
Hoecker CC, Kanegaye JT. First place winner: Recurrent febrile
seizures: an unusual presentation of nutritional rickets. J Emerg
Med 2002; 23(4): 367-370.
https://doi.org/10.1016/s0736-4679(02)00570-x
Khadilkar A, Khadilkar V, Chinnappa J, Rathi N, Khadgawat R,
Balasubramanian S, et al. Prevention and treatment of vitamin D
and calcium deficiency in children and adolescents: Indian
Academy of Pediatrics (IAP) Guidelines. Indian Pediatr 2017;
(7): 567-573. https://doi.org/10.1007/s13312-017-1070-x
Sujatha B, Narayan K, Nair LDV, Shanmuganathan H. Impact of
nutritional status and vitamin D levels in children with febrile
seizure from a Suburban Tertiary Hospital in Tamil Nadu, India.
J Clin Diagn Res 2020; 14(9): 6-10.
http://doi.org/10.7860/JCDR/2020/45324.14015
Rabbani A, Alavian S-M, Motlagh ME, Ashtiani MT, Ardalan G,
Salavati A, et al. Vitamin D insufficiency among children and
adolescents living in Tehran, Iran. J Trop Pediatr 2008; 55(3):
-191. https://doi.org/10.1093/tropej/fmn078
Hussain S, Tarar SH, Sabir MU. Febrile seizures: demographic,
clinical and etiological profile of children admitted with febrile
seizures in a tertiary care hospital. J Pak Med Assoc 2015; 65(9):
-1010.
Holló A, Clemens Z, Kamondi A, Lakatos P, Szűcs A. Correction
of vitamin D deficiency improves seizure control in epilepsy: a
pilot study. Epilepsy Behav 2012; 24(1): 131-133.
https://doi.org/10.1016/j.yebeh.2012.03.011
Sharawat IK, Singh J, Dawman L, Singh A. Evaluation of risk
factors associated with first episode febrile seizure. J Clin Diagn
Res 2016; 10(5): SC10–SC13.
https://doi.org/10.7860%2FJCDR%2F2016%2F18635.7853
Namakin K, Zardast M, Sharifzadeh G, Bidar T, Zargarian S.
Serum Trace elements in febrile seizure: a case-control study.
Iran J Child Neurol 2016; 10(3): 57-60.
Srinivasa S, Manjunath MN. Serum zinc levels in children with
febrile seizures. J Evol Med Dent Sci 2014; 3(12): 2983-2989.
Bhat JA, Bhat TA, Sheikh SA, Wani ZA, Ara R. Status of 25-
hydroxy vitamin D level in simple febrile seizures and its
correlation with recurrence of seizures. Avicenna J Med 2020;
(1): 6-9. https://doi.org/10.4103%2Fajm.ajm_57_19
Heydarian F, Bakhtiari E, Golmakani H, Ghasemi NF, Heidarian
M. Serum level of vitamin D and febrile seizure? A clinical
study. Iran J Child Neurol 2020; 14 (3): 77-82.
Di-Somma C, Scarano E, Barrea L, Zhukouskaya VV, Savastano
S, Mele C, et al. Vitamin D and neurological diseases: an
endocrine view. Int J Mol Sci 2017; 18 (11): 2482.
https://doi.org/10.3390%2Fijms18112482
Singh V, Sharma P, Dewan D. Association of vitamin D levels
with simple febrile seizures in under five children: a case control
study. Int J Contemp Pediatr 2019; 6 (2): 365-368.
Downloads
Published
Issue
Section
How to Cite
