Paediatric Patients-Based Case-Control Analysis: The Association Between Serum Vitamin D Levels And Febrile Seizures
DOI:
https://doi.org/10.51253/pafmj.v74i2.6801Keywords:
Febrile seizures, hypovitaminosis, paediatric population, vitamin DAbstract
Objective: To determine the association between serum vitamin D levels and febrile seizures in the paediatric patients.
Study Design: Case-Control Study.
Place and Duration of Study: Abbasi Shaheed Hospital, Karachi Pakistan, from Mar 2020 to Mar 2021.
Methodology: The study included all pyrexia paediatric patients, both with and without febrile seizures, as cases and controls. Children aged below six months or older than 60 months, with a previous history of afebrile seizures, diagnosed with central nervous system infection, dehydration, or electrolyte disturbance, were excluded from the study. Serum vitamin D levels and other demographic data were documented.
Results: The study included 86 cases and controls. The mean age of cases was 28.07±16.47, and the controls were 26.38±15.72 months. The rate of vitamin D insufficiency was three times more likely in cases compared to controls, i.e. [OR, 95% CI: 3.95 (2.084—7.489)] with p=0.0001.
Conclusion: Vitamin D deficiency is substantially more likely in the case than in the control group. As a result, children with febrile seizures should have their serum vitamin D levels tested.
Downloads
Metrics
References
Natsume J, Hamano SI, Iyoda K, Kanemura H, Kubota M,
Mimaki M, et al. New guidelines for management of febrile
seizures in Japan. Brain Dev 2017; 39(1): 2-9.
https://doi.org/10.1016/j.braindev.2016.06.003
Habib Z, Akram S, Ibrahim S, Hassan B. Febrile seizures: factors
affecting risk of recurrence in Pakistani children presenting at
The Aga Khan University Hospital. J Pak Med Assoc 2003; 53(1):
-17.
Al Morshedy S, Elsaadany HF, Ibrahim HE, Sherif AM, Farghaly
MA, Allah MA, et al. Interleukin-1β and interleukin-1receptor
antagonist polymorphisms in Egyptian children with febrile
seizures: a case-control study. Medicine 2017; 96(11): 1-6.
https://doi.org/10.1097/md.0000000000006370
Kumar N, Midha T, Rao YK. Risk factors of recurrence of febrile
seizures in children in a tertiary care hospital in Kanpur: a one
year follow up study. Ann Indian Acad Neurol 2019; 22(1): 31-
https://doi.org/10.4103/aian.aian_472_17
Renda R, Yüksel D, Gürer YY. Evaluation of patients with febrile
seizure: risk factors, reccurence, treatment and prognosis.
Pediatr Emerg Care 2020; 36(4): 173-177.
https://doi.org/10.1097/pec.0000000000001173
Hoecker CC, Kanegaye JT. First place winner: Recurrent febrile
seizures: an unusual presentation of nutritional rickets. J Emerg
Med 2002; 23(4): 367-370.
https://doi.org/10.1016/s0736-4679(02)00570-x
Khadilkar A, Khadilkar V, Chinnappa J, Rathi N, Khadgawat R,
Balasubramanian S, et al. Prevention and treatment of vitamin D
and calcium deficiency in children and adolescents: Indian
Academy of Pediatrics (IAP) Guidelines. Indian Pediatr 2017;
(7): 567-573. https://doi.org/10.1007/s13312-017-1070-x
Sujatha B, Narayan K, Nair LDV, Shanmuganathan H. Impact of
nutritional status and vitamin D levels in children with febrile
seizure from a Suburban Tertiary Hospital in Tamil Nadu, India.
J Clin Diagn Res 2020; 14(9): 6-10.
http://doi.org/10.7860/JCDR/2020/45324.14015
Rabbani A, Alavian S-M, Motlagh ME, Ashtiani MT, Ardalan G,
Salavati A, et al. Vitamin D insufficiency among children and
adolescents living in Tehran, Iran. J Trop Pediatr 2008; 55(3):
-191. https://doi.org/10.1093/tropej/fmn078
Hussain S, Tarar SH, Sabir MU. Febrile seizures: demographic,
clinical and etiological profile of children admitted with febrile
seizures in a tertiary care hospital. J Pak Med Assoc 2015; 65(9):
-1010.
Holló A, Clemens Z, Kamondi A, Lakatos P, Szűcs A. Correction
of vitamin D deficiency improves seizure control in epilepsy: a
pilot study. Epilepsy Behav 2012; 24(1): 131-133.
https://doi.org/10.1016/j.yebeh.2012.03.011
Sharawat IK, Singh J, Dawman L, Singh A. Evaluation of risk
factors associated with first episode febrile seizure. J Clin Diagn
Res 2016; 10(5): SC10–SC13.
https://doi.org/10.7860%2FJCDR%2F2016%2F18635.7853
Namakin K, Zardast M, Sharifzadeh G, Bidar T, Zargarian S.
Serum Trace elements in febrile seizure: a case-control study.
Iran J Child Neurol 2016; 10(3): 57-60.
Srinivasa S, Manjunath MN. Serum zinc levels in children with
febrile seizures. J Evol Med Dent Sci 2014; 3(12): 2983-2989.
Bhat JA, Bhat TA, Sheikh SA, Wani ZA, Ara R. Status of 25-
hydroxy vitamin D level in simple febrile seizures and its
correlation with recurrence of seizures. Avicenna J Med 2020;
(1): 6-9. https://doi.org/10.4103%2Fajm.ajm_57_19
Heydarian F, Bakhtiari E, Golmakani H, Ghasemi NF, Heidarian
M. Serum level of vitamin D and febrile seizure? A clinical
study. Iran J Child Neurol 2020; 14 (3): 77-82.
Di-Somma C, Scarano E, Barrea L, Zhukouskaya VV, Savastano
S, Mele C, et al. Vitamin D and neurological diseases: an
endocrine view. Int J Mol Sci 2017; 18 (11): 2482.
https://doi.org/10.3390%2Fijms18112482
Singh V, Sharma P, Dewan D. Association of vitamin D levels
with simple febrile seizures in under five children: a case control
study. Int J Contemp Pediatr 2019; 6 (2): 365-368.
Downloads
Published
How to Cite
Issue
Section
