Comparison of Volumetric Modulated Arc Therapy and Fixed Field Intensity Modulated Radiotherapy for Radical Treatment of Early Prostate Cancer using Hypofractionated Radiotherapy

Zeeshan Ahmed Alvi; Sameed Hussain; Muhammad Imran Khan Wajid; Omer Riaz; Muhammad Yousaf Khan; Talha Maqsood; Khurram Khan

doi:10.51253/pafmj.v73i3.7406

Authors

Zeeshan Ahmed Alvi Department of Medicine, Combined Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Sameed Hussain Department of Medicine, Combined Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Muhammad Imran Khan Wajid Department of Medicine, Combined Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Omer Riaz Department of Medicine, Combined Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Muhammad Yousaf Khan Department of Medicine, Combined Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Talha Maqsood Department of Medicine, Combined Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Khurram Khan Department of Medicine, Combined Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan

DOI:

https://doi.org/10.51253/pafmj.v73i3.7406

Keywords:

Hypofractionated radiotherapy, Intensity-modulated radiation therapy, Prostate cancer, Volumetric modulated arc therapy

Abstract

Objective: To investigate the dosimetric advantages of volumetric modulated arc therapy over intensity-modulated radiation therapy for radical treatment of early-stage prostate cancer.

Study Design: Retrospective longitudinal study.

Place and Duration of Study: Department of Radiation Oncology, Combined Military Hospital, Rawalpindi Pakistan, from Jan to Jun 2019.

Methodology: Two treatment plans; one volumetric modulated arc therapy and other intensity-modulated radiation therapy, were made for 13 patients undergoing radical radiotherapy for early prostate cancer. Conformity index, Homogeneity index, the volume of rectum and bladder receiving a dose of 50 Gy or more, monitor units employed and treatment delivery time were compared between both techniques.

Results: Volumetric modulated arc therapy plans showed statistically better conformity index and Homogeneity index with significantly lower doses to the rectum and bladder than intensity-modulated radiation therapy plans. The number of monitor units (MUs) employed and treatment delivery time were also reduced significantly with volumetric modulated arc therapy.

Conclusion: Volumetric modulated arc therapy generates dose-metrically better radiotherapy plans than intensity-modulated radiation therapy and can deliver the required dose faster.
Keywords: Hypofractionated radiotherapy, Intensity-modulated radiation therapy, Prostate cancer, Volumetric modulated arc
therapy.