DYSLIPIDEMIA IN PREGNANCY AND ITS CORRELATION WITH PREECLAMPSIA

Abstract

Objective: To evaluate lipidprofile amongst patients diagnosed with preeclampsia and compare it with normal pregnant patients.

Study Design: Cross-sectional comparative study.

Place and Duration of Study: Obstetrics Unit, Combined Military Hospital Rawalpindi, from Jan to Mar 2021.

Methodology: A total of 80 patients were enrolled and divided into two groups. Group A preeclampsia patients and group B normotensive pregnant patients in third trimester. Inclusion criteria were patients between 20-35 years in third trimester of pregnancy. Patients with preexisting hypertension, diabetes, autoimmune disease and renal problems were excluded. Demographic and reproductive profiles including age, parity, period of gestation and body mass index (BMI) noted. Blood samples after 12 hours of fasting were obtained. Serum total cholesterol, high density lipoproteins (HDL), low density lipoproteins (LDL), serum triglycerides and very low density lipoproteins (VLDL) levels calculated. Demographic profile and test results of the two groups were compared. p-value of ≤0.05 was considered statistically significant.

Results: A total of 80 patients were enrolled in the study. Mean age of two groups was 28.6 ± 3.8 yrs, mean parity 1.8 ± 1.1, gestational age 33.6 ± 2.6, body mass index 27.7 ± 2. Mean values calculated of the lipid profile of both groups was cholesterol 5.22 ± 1.2, high density lipoproteins 1.68 ± 0.65, low density lipoproteins 3.07 ± 1.1, triglycerides 2.5 ± 0.93, very low density lipoproteins 1.24 ± 0.44. Difference between age, parity, gestational age and body mass index was not significant between the two groups but difference between serum cholesterol and triglyceride levels was significant (p<0.0001).

Conclusion: Our pregnant population generally has raised lipid levels. Women with preeclampsia have lipid profile derangements which are significant in comparison to normotensive patients.