Intralesional Tranexamic Acid vs Intralesional Autologous Platelet Rich Plasma in the Treatment of Resistant Melasma
DOI:
https://doi.org/10.51253/pafmj.v76iSUPPL-1.8989Keywords:
Melasma, Platelet Rich Plasma, Tranexamic AcidAbstract
Objective: To compare intralesional tranexamic acid with intralesional autologous platelet rich plasma in the treatment of resistant melasma
Study Design: Quasi-experimental study
Place and Duration of Study: Departments of Dermatology, Pak Emirates Military Hospital and Combined Military Hospital Rawalpindi, Pakistan from Jun 2021 to May 2022.
Methodology: One hundred and forty diagnosed patients of melasma were randomized in 2 equal groups. Group-A was treated with Platelet rich plasma (PRP) mesotherapy while Group-B with intralesional Tranexamic acid. Melasma area treatment index (MASI) scores were calculated at baselines and at 16 weeks to monitor effectivity of both treatment modalities.
Results: Pretreatment MASI scores in Groups A and B were 21.08±6.08 and 21.44±6.36 (p=0.71). Post treatment MASI were significantly better at 16 weeks in Group-A at 7.79±1.86 as compared to Group-B at 9.15±4.69 (p=0.01). Difference in adverse effect profile between both groups was not significant.
Conclusion: Platelet Rich Plasma mesotherapy is a better treatment option for management of Melasma as compared to intradermal Tranexamic Acid.
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Copyright (c) 2026 Maryam Rehman, Asher Ahmed Mashhood, Shamaila Khan, Mehmood Hussain, Javeria Hafeez, Iqra Ghous
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