RANITIDINE POTENTIATES THE EFFECT OF METOCLOPRAMIDE ON GASTROINTESTINAL MOTILITY IN RABBITS

Metoclopramide On Gastric Motility

Authors

  • Aroosa Ishtiaq Butt Fazaia Medical College Islamabad Pakistan
  • Bushra Tayyaba Khan Army Medical College/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Salman Bakhtiar Rehman Medical College Peshawar Pakistan

Keywords:

Gastro-intestinal motility, Metoclopramide, Prokinetic, Ranitidine

Abstract

Objective: To explore the synergistic potential of ranitidine on prokinetic activity of metoclopramide on isolated duodenal model of rabbit.
Study Design: Laboratory based randomized controlled trial.
Place and Duration of Study: Multi-disciplinary Laboratory, Army Medical College, Rawalpindi with study duration of 12 months.
Material and Methods: Dose response curve of ranitidine and metoclopramide were constructed by adding cumulatively increasing concentrations of the two drugs on isolated duodenum of rabbits separately. A fixed dose of ranitidine was then selected for studying its potentiating effect on increasing concentrations of metoclopramide on isolated duodenum of rabbits utilizing iWorx Data acquisition unit AHK/214.
Results: Ranitidine enhances the prokinetic effect of metoclopramide.
Conclusion: Ranitidine enhances the contractile effect of the gut in vitro and potentiates the prokinetic effect of metoclopramide. So we conclude that ranitidine is a better choice for patients suffering from gastroesophageal reflux disease (GERD) along with gastroparesis as it enhances the prokinetic effect of metoclopramide.

 

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Published

31-12-2016

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Section

Original Articles

How to Cite

1.
Butt AI, Khan BT, Bakhtiar S. RANITIDINE POTENTIATES THE EFFECT OF METOCLOPRAMIDE ON GASTROINTESTINAL MOTILITY IN RABBITS: Metoclopramide On Gastric Motility. Pak Armed Forces Med J [Internet]. 2016 Dec. 31 [cited 2024 Nov. 10];66(6):778-83. Available from: https://www.pafmj.org/PAFMJ/article/view/913