Evaluating the Association of Hyperuricemia in End-Stage Renal Disease Patients on Hemodialysis at a Tertiary Care Hospital
DOI:
https://doi.org/10.51253/pafmj.v75i4.9450Keywords:
Chronic Kidney Disease, Glomerular Filtration Rate, Hemodialysis, Hyperuricemia, Peritoneal Dialysis, Renal Replacement Therapy, Uric Acid.Abstract
Objective: To highlight the association of hyperuricemia in patients of Chronic Kidney Disease stage 5 on Hemodialysis (CKD-5D) at a tertiary care hospital.
Study Design: Cross-sectional study.
Place and Duration of Study: Department of Nephrology and Dialysis Unit, Pak Emirates Military Hospital, Rawalpindi Pakistan, from Jul to Dec 2021.
Methodology: Using a consecutive sampling technique, CKD patients of either gender with age >15 years, both dialysis dependent (CKD-5D) and non-dialysis dependent (CKD-5ND), were included and divided into two groups of 80 each. Serum uric acid levels of both groups (CKD-5ND and CKD-5D) patients were assessed and analyzed. Measures of association odds ratio and the prevalence ratio, were calculated.
Results: The mean age was 53.76±18.26 years in Group-A (CKD-5ND) and 52.46±17.50 years in Group-B (CKD-5D) (p=0.667). Out of the total 80 CKD-5D patients in Group-B, 14(17.5%) underwent HD once weekly, 37(46.3%) twice weekly, and 29(36.3%) undergoing hemodialysis thrice weekly. CKD-5ND patients tend to have higher levels of uric acid as compared to CKD-5D patients, 51(63.8%) vs 33(41.3%), respectively (p=0.004). Patients undergoing once weekly hemodialysis had higher levels of uric acid, 9(27.3%), and patients undergoing twice or thrice weekly hemodialysis, 17(51.5%) and 7(21.2%), had hyperuricemia, respectively (p=0.032).
Conclusion. There is a high prevalence of hyperuricemia in CKD patients, and with declining eGFR, uric acid levels increase. Patients undergoing thrice weekly maintenance hemodialysis had a lower prevalence of raised uric acid levels with once weekly hemodialysis and CKD patients without hemodialysis.
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