VALIDITY OF COMPUTED TOMOGRAPHY SCAN FOR THE DIAGNOSIS OF OVARIAN CARCINOMA AND ITS STAGES

Validity of CT Scan for Ovarian Carcinoma

Abstract

Original Article

Objective: To determine the validity of CT scan for the diagnosis of ovarian carcinoma and its stages taking histopathology as gold standard

Study Design: Cross sectional validation study.

Place and Duration of Study: The study was conducted in the Department of Radiology, DHQ Hospital Rawalpindi, RMC and Allied hospitals from October 2011 to March 2012.

Patients and Methods: This study included one hundred thirty six consecutive subjects with symptoms of ovarian pelvic mass with an age range of 20 years to 70 years and pre-operative CA -125 level were enrolled in the study by the Principle Investigator (PI).

All 136 patients were gone through CECT scan. Imaging findings of all patients were compared with results of histologic examinationto determine the diagnostic accuracy of CECT scan in the evaluation of disease status. The Histopathological staging of ovarian carcinoma was obtained on the basis of FIGO Classification. Histopathological findings of each patient were obtained from laboratory were actually reported by consultant Pathologist

Result: The mean age of the patient is 50.37 years. The sensitivity and specificity of CT in diagnosis of malignant ovarian carcinoma is 100% with the p value was 0.0001 and 84.85% respectively. The Positive Predictive Value (PPV) and Negative Predictive Value (NPV) is 95.37% and 100% respectively, taking histopathology as Gold Standard. The overall accuracy of CT in diagnosis and staging of ovarian carcinoma is 96% and 93% respectively.

Conclusion: The beneficial effect of the study is to find a non-invasive, less time consuming and relatively easy modality for the diagnosis of ovarian carcinoma including its staging. Prompt diagnosis will lead to instant decision making for the management of this debilitating disease