COMPARISON OF PREEMPTIVE GABAPENTIN WITH PREGABALIN FOR RELIEF OF POSTOPERATIVE PAIN IN PATIENTS UNDERGOING CHOLECYSTECTOMY

Comparison of Preemptive Gabapentin With Pregabalin in Cholecystectomy

Authors

  • Shahid Maqsood, Combined Military Hospital Sargodha/National University of Medical Sciences (NUMS) Pakistan
  • Rao Ali Shan Khan *Combined Military Hospital Peshawar/National University of Medical Sciences (NUMS) Pakistan,
  • Abdullah Arshad 144 Medical Battalion Goma, Siachin Galcier Pakistan

Keywords:

Analgesia, Cholecystectomy, Gabapentin, Pregabalin.

Abstract

Objective: To compare the mean time duration of patient's first request for analgesic for pain relief after open cholecystectomy with preoperative use of pregabalin or gabapentin.
Study Design: Randomized controlled trial.
Place and Duration of Study: Department of anesthesia, Combined Military Hospital (CMH) Peshawar during a period of six months, from May 2014 to Nov 2014.
Material and Methods: This study included a total of 126 patients with clinical and ultrasound diagnosis of acute cholecystitis. Patients were distributed randomly into two groups equally (63 patients in each group). Group A was given 300mg pregabalin and group B was given 900mg gabapentin one hour before surgery by mouth.
Results: Mean age was 46.68 ± 8.074 years for group A and 46.33 ± 8.046 years for group B. In group A, there were 49.2% males and 50.8% females while in group B, there were 42.9% males and 57.1% females. Weight of patients was 68.54 ± 6.283 kg in group A and 69.75 ± 5.778 kg in group B respectively. Mean time duration score was 37.48 ± 7.175 minutes and 18.27 ± 3.366 minutes in group A and B, respectively (p<0.001).
Conclusion: Preoperative use of pregabalin provides significantly prolonged postoperative analgesia compared to gabapentin after open cholecystectomy.

 

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Published

30-10-2017

Issue

Section

Original Articles

How to Cite

1.
Maqsood, S, Shan Khan RA, Arshad A. COMPARISON OF PREEMPTIVE GABAPENTIN WITH PREGABALIN FOR RELIEF OF POSTOPERATIVE PAIN IN PATIENTS UNDERGOING CHOLECYSTECTOMY: Comparison of Preemptive Gabapentin With Pregabalin in Cholecystectomy. Pak Armed Forces Med J [Internet]. 2017 Oct. 30 [cited 2024 Jun. 14];67(5):843-46. Available from: https://www.pafmj.org/PAFMJ/article/view/986