Comparison of Platelet Indices in Women with Preeclampsia Versus Women Without Preeclampsia

Umme  Habiba; Tooba  Ammar; Ehtesham ul  Haq; Amna  Parveen; Rabiya  Jamil; Syeda Azka  Waqar

doi:10.51253/pafmj.v75i2.11765

Authors

Umme Habiba Department of Pathology, University of Health Sciences Lahore Pakistan
Tooba Ammar Shaikh Zayed Medical Complex Lahore Pakistan
Ehtesham ul Haq RLKU Medical & Dental College Lahore Pakistan
Amna Parveen Lady Aitcheson Hospital Lahore Pakistan
Rabiya Jamil Amna Inayat Medical College Lahore Pakistan
Syeda Azka Waqar Fatima Memorial Hospital Shadman Lahore Pakistan

DOI:

https://doi.org/10.51253/pafmj.v75i2.11765

Keywords:

Complications, Hypertension, Preeclampsia, Platelet Indices

Abstract

Objective: To determine difference in platelet indices among pregnant ladies with preeclampsia as compared to those pregnant ladies without preeclampsia using platelet indices as biomarkers for predicting the disease and its severity.

Study Design: Comparative cross sectional study.

Place and Duration of Study: Department of Pathology and The Department of Obstetrics and Gynecology, Rashid Latif Khan University Medical and Dental College Lahore, Pakistan from Jan-Jun 2023.

Methodology: Pregnant women falling on inclusion criteria were included in this study using nonprobability consecutive sampling technique. Complete blood count with platelet indices, and serum sugar were determined. Study sample was divided into two groups. Patients without preeclampsia were placed in Group-A (n=60), those with preeclampsia were put into Group-B (n=60). Platelet indices were compared between two groups including platelet count, mean platelet volume (MPV), Plateletcrit and platelet distribution width (PDW).

Results: Total 120 cases with preeclampsia were studied. Mean hemoglobin level was 13.24±2.10 g/dl in Group-A, 12.73±1.80 g/dl in Group-B. Mean platelet count was 277±88 x109/L in Group-A, 301±84 x109/L in Group-B. MPV was 12.07±1.03fL in Group-A and 11.21±1.31fL in Group-B.

Conclusion: Platelet indices are altered among the patients with preeclampsia as compared to normal individuals, hence indicating as important biomarker for assessing the disease.

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References

Temur M, Taşgöz FN, Çift T, Serpim G, Üstünyurt E. Role of platelet indices in prediction of preeclampsia. Ginekol Pol 2021; 92(11): 792-796.

https://doi.org/10.5603/gp.a2021.0056

Bawore SG, Adissu W, Niguse B, Larebo YM, Ermolo NA, Gedefaw L. A pattern of platelet indices as a potential marker for prediction of pre-eclampsia among pregnant women attending a Tertiary Hospital, Ethiopia: A case-control study. Plos One 2021; 16(11): e0259543.

https://doi.org/10.1371/journal.pone.0259543

Wu J, Zhang J, Yang J, Zheng TQ, Chen YM. Association between platelet indices and risk of preeclampsia in pregnant women. J Obs Gynaecol 2022; 42(7): 2764-2770.

https://doi.org/10.1080/01443615.2022.2109136

Elmaradny E, Alneel G, Alkhattaf N, AlGadri T, Albriakan N. Predictive values of combined platelet count, neutrophil-lymphocyte ratio, and platelet-lymphocyte ratio in preeclampsia. J Obs Gynaecol 2022 ; 42(5): 1011-1017.

https://doi.org/10.1080/01443615.2021.1986476

Abd El-Rahman S, Sonosy DA, Abbas AM, Abdou MA. Evaluation of Platelet Count and Platelet Indices in The Diagnosis of Preeclampsia and Eclampsia: A Cross-Sectional Study. J Women’s Health Res1. 2020; 101(1).

Manchanda J, Malik A. Study of platelet indices in pregnancy-induced hypertension. Med J Arm Force Ind 2020; 76(2): 161-165. https://doi.org/10.1016/j.mjafi.2019.02.006

Sachan R, Patel ML, Sachan P, Shyam R. Role of platelet count and mean platelet volume and red cell distribution width in the prediction of preeclampsia in early pregnancy. J Family Med Prim Care 2021; 10(2): 838.

https://doi.org/10.4103/jfmpc.jfmpc_1528_20

Umezuluike, B, Anikwe C, Nnachi C, Iwe C, Ifemelumma C , Dimejesi O. Correlation of platelet parameters with adverse maternal and neonatal outcomes in severe preeclampsia: A case-control study.Heliyon 7(12), e08484.

https://doi.org/10.1016/j.heliyon.2021.e08484

Walle M, Gelaw Y, Getu F, Asrie F, Getaneh Z. Preeclampsia has an association with both platelet count and mean platelet volume: a systematic review and meta-analysis. Plos One 2022; 17(9): e0274398. https://doi.org/10.1371/journal.pone.0274398

Mohamed Ahmed KA, FadlElseed EO, Mohamed AM, Hassan MI, Talha AA. Impact of Preeclampsia on Platelet Count and Platelet Indices among Sudanese Pregnant Women in Gezira State. J Gynecol Reprod Med 2021; 5(2): 163-166.

Salman AF, Hameed BH, Ali EA. The Value of Platelet Indices and platelet to lymphocyte ratio as predictors of severity of Preeclampsia in Iraqi women. J Biotechnol Res Center 2021; 15(2): 5-12. https://doi.org/10.24126/jobrc.2021.15.2.604

Lin SS, Wang CR, Wei DM, Lu JH, Chen XJ, Chen QZ et al. Incremental predictive value of platelet parameters for preeclampsia: results from a large prospective cohort study. BMC Pregnancy Childbirth 2023; 23(1): 1-1.

https://doi.org/10.1186/s12884-023-05661-y

Ye D, Li S, Ma Z, Ding Y, He R. Diagnostic value of platelet to lymphocyte ratio in preeclampsia: a systematic review and meta-analysis. J Matern-Feta Neonatal Med 2023; 36(2): 2234540. https://doi.org/10.1080/14767058.2023.2234540

Taşin C, Bağli İ, Çolak H, Çiftçi Rs, Aytan H. Evaluation of Platelet Indices in Patients with Preeclampsia and Gestational Hypertension. Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi 2021; 18(3): 888-893.

https://doi.org/10.38136/jgon.854818

Choudhry SS, Qureshi MN, Jabbar S, Khan KU, Kashif S, Khan MS. Evaluation of Platelet Count among Women with Preeclampsia: A Case-Control Study from Pakistan. Pak J Med Health Sci. 2022; 16(07): 394.

https://doi.org/10.53350/pjmhs22167394

Nayyar MW, Mahmood A, Zohra S, Khurshid A, Ali S, Zahir S. Platelet Indices in Pregnant and Non Pregnant Females: A Comparative Study at a Tertiary Care Diagnostic Laboratory. Pak Armed Forces Med J 2022; 72(3): 831-834.

https://doi.org/10.51253/pafmj.v72i3.6922

Saeed H, Iqbal S, Tehseen S, Aziz M. Assessment of Diagnostic accuracy of Platelet Distribution Width as predictor of Preelampsia. Pak J Med Health Sci 2022; 16(09): 164.

https://doi.org/10.53350/pjmhs22169164

Manzoor F, Rahat F, Ashique F, Waheed R, Iqbal S, Chughtai AS. Association of Preeclampsia with Low Platelet Count among Pregnant Females Presenting during Third Trimester. Pak J Med Health Sci 2022; 16(03): 126.

https://doi.org/10.53350/pjmhs22169164

Rashid S, Patange RP. Role of platelet indices in non-thrombocytic pih. Int J Health Sci(I): 7079-7097.

https://doi.org/10.53730/ijhs.v6nS1.6534

Changmai NP, Deori R, Boro G, Khakhlari S. Platelet Count and Platelet Indices In Preeclampsia: A Cross-Sectional Study. Int J Acad Med Pharm 2023; 5(3): 756-759.

https://doi.org/10.47009/jamp.2023.5.3.156

Iskender D, Obut M, Keles A, Arat O, Celik O, Sarikaya D et al. Diagnostic performance of hematological indices in early and late preeclampsia. Med Sci. 2022; 11(1): 148.

http://doi.org/10.5455/medscience.2021.10.357