Clinical Outcome Analysis of Surgical Intervention in Diagnosed Lung Cancer Patients at a Tertiary Care Thoracic Surgery Department

Authors

  • Muhibullah Department of Thoracic Surgery, Combined Military Hospital, Rawalpindi/National University of Medical Sciences (NUMS) Pakistan
  • Farhan Ahmed Majeed Department of Thoracic Surgery, Combined Military Hospital, Rawalpindi/National University of Medical Sciences (NUMS) Pakistan
  • Bilal Umair Department of Thoracic Surgery, Combined Military Hospital, Rawalpindi/National University of Medical Sciences (NUMS) Pakistan
  • Farhanullah Department of Thoracic Surgery, Combined Military Hospital, Rawalpindi/National University of Medical Sciences (NUMS) Pakistan
  • Adnan Younis Panni Department of Thoracic Surgery, Combined Military Hospital, Rawalpindi/National University of Medical Sciences (NUMS) Pakistan
  • Nabeela Farhan Department of Thoracic Surgery, Combined Military Hospital, Rawalpindi/National University of Medical Sciences (NUMS) Pakistan

DOI:

https://doi.org/10.51253/pafmj.v76iSUPPL-3.12618

Keywords:

Advanced diagnosis, Chemotherapy, Lung Cancer, Surgery

Abstract

Objective: The current study aimed to assess the association of different stages of lung cancer with various demographics and clinical variables.

Study Design: Prospective Longitudinal Study.

Place and Duration of Study: Department of Thoracic, CMH, Rawalpindi, Pakistan, from Jan to Sep 2024.

Methodology: The study participants were patients attending the outpatient department and suspected of lung cancer. The inclusion criteria were age ≥ 18 years, diagnosed with lung cancer, and a resident of Pakistan. The data analysis was carried out using a statistical package for the social sciences (SPSS v25). Descriptive statistics were applied to describe the data. To identify the determinants of late-stage diagnosis, a logistic regression analysis was used.

Results: A total of 45 patients with lung cancer were included in the current study. Most of the patients had a diagnosis of stage IV (73.3%). Tumors were peripheral (57.8%), had primary etiology (91.1%), and were non-small cell lung cancer (NSCLC) (72.7%). Chemotherapy was used as treatment in almost half of the patients (48.8%), and interventions, including Pleurodesis (46.2%), were predominantly. The logistic regression analysis showed that males, age >60 years, and smoking were associated with late-stage diagnosis.

Conclusion: In the current study, most of the patients were referred to stage IV, which was treated on the lines of palliation. Early detection in high-risk identified patients should be offered low-dose CT scans.

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References

1. Siegel RL, Miller KD, Wagle NS, Jemal A. Cancer statistics, 2023. CA Cancer J Clin 2023; 73(1): 17-48.

https://doi:10.3322/caac.21763

2. Sasaki T, Kuno H, Hiyama T, Oda S, Masuoka S, Miyasaka Y, et al. 2021 WHO Classification of Lung Cancer: Molecular Biology Research and Radiologic-Pathologic Correlation. Radiographics 2024; 44(3):e 230136.

https://doi:10.1148/rg.230136.

3. Leiter A., Veluswamy RR, Wisnivesky JP. The global burden of lung cancer: current status and future trends. Nat Rev Clin Oncol 2023; 20(9): 624-639.

https://doi.org/10.1038/s41571-023-00798-3

4. Lam DC, Liam CK, Andarini S, Park S, Tan DSW, Singh N, et al. Lung Cancer Screening in Asia: An Expert Consensus Report. J Thorac Oncol 2023; 18(10): 1303-1322.

https://doi.org/10.1016/j.jtho.2023.06.014

5. Jovanoski N, Bowes K, Brown A, Belleli R, Di Maio D, Chadda S, et al. Survival and quality-of-life outcomes in early-stage NSCLC patients: a literature review of real-world evidence. Lung Cancer Manag 2023; 12(3): LMT60.

https://doi.org/10.2217/lmt-2023-0003

6. Yao G, Lai JS, Garcia SF, Yount S, Cella D. Positive and negative psychosocial impacts on cancer survivors. Sci Rep 2023; 13(1): 14749.

https://doi.org/10.1038/s41598-023-41822-x

7. Fu Y, Liu J, Chen Y, Liu Z, Xia H, Xu H. Gender disparities in lung cancer incidence in the United States during 2001–2019. Sci Rep 2023; 13(1):12581.

https://doi.org/10.1038/s41598-023-39440-8

8. Release Notice - Canadian Cancer Statistics: A 2020 special report on lung cancer. Health Promot Chronic Dis Prev Can 2020; 40(9): 325. https://doi.org/10.24095/hpcdp.40.10.05

9. May L, Shows K, Nana-Sinkam P, Li H, Landry JW. Sex differences in lung cancer. Cancers 2023; 15(12): 3111. https://doi:10.3390/cancers15123111

10. Ragavan M, Patel MI. The evolving landscape of sex-based differences in lung cancer: a distinct disease in women. Eur Respir Rev 2022; 31(163): 210100.

https://doi.org/10.1183/16000617.0100-2021

11. Bade BC, Dela Cruz CS. Lung Cancer 2020: Epidemiology, Etiology, and Prevention. Clin Chest Med 2020; 41(1): 1-24.

https://doi.org/10.1016/j.ccm.2019.10.001

12. Gee K, Yendamuri S. Lung cancer in females-sex-based differences from males in epidemiology, biology, and outcomes: a narrative review. Transl Lung Cancer Res 2024; 13(1): 163-178.

https://doi.org/10.21037/tlcr-23-744

13. Corrales L, Rosell R, Cardona AF, Martín C, Zatarain-Barrón ZL, Arrieta O. Lung cancer in never smokers: the role of different risk factors other than tobacco smoking. Crit Rev Oncol Hematol 2020; 148: 102895.

https://doi.org/10.1016/j.critrevonc.2020.102895

14. Wang, X., et al., association between smoking history and tumor mutation burden in advanced non–small cell lung cancer. Cancer res 2021; 81(9): 2566-2573.

https://doi.org/10.1158/0008-5472.CAN-20-3991

15. Nooreldeen R, Bach H. Current and Future Development in Lung Cancer Diagnosis. Int J Mol Sci 2021; 22(16): 8661.

https://doi.org/10.3390/ijms22168661

16. Alam A, Ansari MA, Badrealam KF, Pathak S. Molecular approaches to lung cancer prevention. Future Oncol 2021; 17(14): 1793-1810.

https://doi.org/10.2217/fon-2020-0789

17. Rizzo S, Del Grande F, Wannesson L, Froesch P, Giannetto G, Petrella F. Recent developments and advances in secondary prevention of lung cancer. Eur J Cancer Prev 2020; 29(4): 321-328. https://doi.org/10.1097/CEJ.0000000000000586

18. Tang FH, Wong HYT, Tsang PSW, Yau M, Tam SY, Law L, et al. Recent advancements in lung cancer research: a narrative review. Transl Lung Cancer Res 2025; 14(3): 975-990.

https://doi.org/10.21037/tlcr-24-979

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Published

30-04-2026

How to Cite

1.
Muhibullah, Farhan Ahmed Majeed, Umair B, Farhanullah, Panni AY, Farhan N. Clinical Outcome Analysis of Surgical Intervention in Diagnosed Lung Cancer Patients at a Tertiary Care Thoracic Surgery Department. Pak Armed Forces Med J [Internet]. 2026 Apr. 30 [cited 2026 Oct. 13];76(SUPPL-3):S504-S508. Available from: https://www.pafmj.org/PAFMJ/article/view/12618