Efficacy of Nasal Intermittent Positive Pressure Ventilation (NIPPV) For Primary Respiratory Support with Respiratory Distress Syndrome (RDS) in Preterm Neonates
DOI:
https://doi.org/10.51253/pafmj.v76iSUPPL-3.13669Keywords:
Bronchopulmonary Dysplasia, Neonatal Outcomes, NCPAP, NIPPV, Preterm Neonates, Respiratory Distress SyndromeAbstract
Objective: To evaluate the clinical results of nasal intermittent positive pressure ventilation (NIPPV) and nasal continuous positive airway pressure (NCPAP) in premature infants suffering from respiratory distress syndrome (RDS).
Study Design: Quasi-Experimental Study.
Place and Duration of Study: Neonatal Intensive Care Units, Combined Military Hospital (CMH), Quetta, Pakistan, from Mar 23 to Jun 24.
Methodology: A total of 148 preterm neonates diagnosed with RDS were included and divided into two equal groups: NCPAP (n=74) and NIPPV (n=74). Data on gestational age, birth weight, APGAR scores, early onset sepsis, and hospitalization duration were collected. Blood gas parameters and neonatal outcomes such as intubation requirement, surfactant administration, hemodynamically significant PDA, IVH grade ≥3, moderate/severe BPD, late-onset sepsis, ROP, and NEC ≥ stage 2 were noted. SPSS used for statistical analysis, and a p-value of less than 0.05 was deemed significant.
Results: Birth weight was higher in the NIPPV group (p=0.030), while other baseline characteristics were comparable. A lower, though statistically non-significant, incidence of intubation within 72 hours (28.4% vs. 37.8%) and moderate/severe BPD (18.9% vs. 8.1%) was noted in the NIPPV group.
Conclusion: NIPPV showed a trend toward improved respiratory outcomes, particularly reduced need for early intubation and lower BPD rates, though not statistically significant. Larger, multicenter trials are needed to establish clinical superiority.
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