Determination of Upper Reference Limit for High-Sensitivity Troponin T in Chronic Kidney Disease Patients

Sehrish Naz; Muhammad Qaiser Alam Khan; Asma Hayat; Sikander Hayat Khan; Sajida Shaheen; Anser Umar Khan

doi:10.51253/pafmj.v76iSUPPL-3.13725

Authors

Sehrish Naz Department of Chemical Pathology, Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS), Rawalpindi Pakistan
Muhammad Qaiser Alam Khan Department of Chemical Pathology, Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS), Rawalpindi Pakistan
Asma Hayat Department of Chemical Pathology, Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS), Rawalpindi Pakistan
Sikander Hayat Khan Department of Chemical Pathology, Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS), Rawalpindi Pakistan
Sajida Shaheen Department of Chemical Pathology, Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS), Rawalpindi Pakistan
Anser Umar Khan Department of Chemical Pathology, Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS), Rawalpindi Pakistan

DOI:

https://doi.org/10.51253/pafmj.v76iSUPPL-3.13725

Keywords:

Cardiac Biomarker, Cardiovascular Disease, Chronic Kidney Disease, Troponin T, Upper Reference Limit

Abstract

Objective: To establish the 99^th percentile of upper reference limit (URL) for high-sensitivity Troponin T (hs-Troponin T) in patients with Chronic Kidney Disease (CKD).

Study Design: Cross-sectional analytical study.

Place and Duration of Study: Department of Chemical Pathology and Endocrinology, Armed Forces Institute of Pathology (AFIP), Rawalpindi Pakistan, from Jan to Jun 2025.

Methodology: A total of 300 males and 300 females were enrolled. Patients with CKD stages 3 to 5, based on estimated glomerular filtration rate (eGFR), between the ages of 18 and 80 years who had no self-reported history of cardiovascular disease were included.

Results: The study participants had a median (interquartile range) of eGFR of 26.62 (15.00 – 38.67) mL/min/1.73m². The data were not normally distributed. The median (IQR) of hs-Troponin T levels was 66 (35.40 – 100.00) ng/L in males and 76.20 (49.00 – 111.00) ng/L in females, with the 99th percentile URL at 402.9 ng/L for males and 264.9 ng/L for females. Therefore, the combined median hs-Troponin T value for both genders was 69.00 ng/L, with an IQR of 40 to 102.75 ng/L. The 99^th percentile URL of hs-Troponin T was 394.74 ng/L. A moderate but statistically significant negative correlation, r = -0.4643 (95% CI), between eGFR and hs-Troponin T levels was identified.

Conclusion: The 99^th percentile URL for hs-Troponin T in CKD patients was markedly elevated compared to that observed in the healthy population. These findings underscore the importance of establishing CKD-specific URL of hs- Troponin T to prevent the misclassification of myocardial infarction..

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Author Biography

Sajida Shaheen, Department of Chemical Pathology, Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS), Rawalpindi Pakistan

Consultant Chemical Pathologist

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