Comparison of Therapeutic Efficacy of Topical Tacrolimus 0.1%  and Topical Dithranol 0.5% in Treatment of Alopecia Areata

Authors

  • Majid Husain Departments of Dermatology, Combined Military Hospital Abottabad /National University of Medical Sciences (NUMS) Pakistan
  • Muhammad Adeel Siddiqui Departments of Dermatology, Combined Military Hospital, Hyderabad /National University of Medical Sciences (NUMS) Pakistan
  • Hina Mazhar Departments of Dermatology, Combined Military Hospital Malir /National University of Medical Sciences (NUMS) Pakistan
  • Zafar Sheikh Departments of Dermatology, Pak Emirates Military Hospital/National University of Medical Sciences (NUMS), Rawalpindi Pakistan
  • Adiba . Departments of Dermatology, Pak Emirates Military Hospital/National University of Medical Sciences (NUMS), Rawalpindi Pakistan
  • Kashifa Yasmeen Departments of Psychology, University of Lahore, Lahore pakistan

DOI:

https://doi.org/10.51253/pafmj.v75iSUPPL-4.5937

Keywords:

Alopecia areata, Anthralin, Tacrolimus.

Abstract

Objective: To compare the therapeutic efficacy of topical Tacrolimus 0.1% and topical Dithranol 0.5% in patients of alopecia areata.

Study Design: Quasi Experimental Study 

Place and Duration of Study: Departments of Dermatology, Combined Military Hospital, Hyderabad and Combined Military Hospital, Abbottabad from Sep 2019-2020.

Methodology: Patients fulfilling the inclusion criteria were selected in the first 1 and a half months, after written informed consent. The patients were divided into two Groups A and B, by lottery method. Group A received topical Tacrolimus 0.1% application twice a day and Group B received topical Dithranol 0.5% application twice a day, for 24 weeks. The response of treatment was calculated by two observers and each of them determined the percentage of hair re growth by comparing the pre and post treatment photographs of the patient at 24 weeks.

Results: More than 80% Hair re - growth was observed in 7(23.33%) of the patients in Tacrolimus Group and 12(40%) of the patients in Dithranol Group.  Therapeutic efficacy of Dithranol was more than Tacrolimus as their comparison revealed p value=0.039.

Conclusion: Therapeutic efficacy of Dithranol is superior to Tacrolimus in treatment of alopecia areata.

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References

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Published

26-05-2025

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Original Articles

How to Cite

1.
Husain M, Siddiqui MA, Mazhar H, Sheikh Z, . A, Yasmeen K. Comparison of Therapeutic Efficacy of Topical Tacrolimus 0.1%  and Topical Dithranol 0.5% in Treatment of Alopecia Areata. Pak Armed Forces Med J [Internet]. 2025 May 26 [cited 2025 Oct. 7];75(SUPPL-4):S632-S635. Available from: https://www.pafmj.org/PAFMJ/article/view/5937