New Onset Neurological Symptoms in Triple-Negative Breast Cancer Patient; Not Always Due to Metastasis

Jhanzeb Iftikhar; Muhammad Abubakar  Sarwar; Syed Abdul Mannan  Hamdani; Musa  Azhar; Shafquat Ali  Khan; Neelam  Siddiqui

doi:10.51253/pafmj.v75iSUPPL-4.5976

Authors

Jhanzeb Iftikhar Department of Medical Oncology, Shaukat Khanum Memorial Cancer Hospital Lahore Pakistan
Muhammad Abubakar Sarwar Department of Medical Oncology, Shaukat Khanum Memorial Cancer Hospital Lahore Pakistan
Syed Abdul Mannan Hamdani Department of Medical Oncology, Shaukat Khanum Memorial Cancer Hospital Lahore Pakistan
Musa Azhar Department of Medical Oncology, Shaukat Khanum Memorial Cancer Hospital Lahore Pakistan
Shafquat Ali Khan Department of Medical Oncology, Shaukat Khanum Memorial Cancer Hospital Lahore Pakistan
Neelam Siddiqui Department of Medical Oncology, Shaukat Khanum Memorial Cancer Hospital Lahore Pakistan

DOI:

https://doi.org/10.51253/pafmj.v75iSUPPL-4.5976

Keywords:

Central nervous system, metastasis, neurological symptoms, triple-negative breast cancer.

Abstract

The prognosis after central nervous system relapse in a triple negative breast cancer is grim. However, brain insult in a triple negative breast cancer is not always due to metastasis and other possibilities should be kept in mind too. We report a case of a young female, who had a local relapse of triple negative breast cancer and developed new onset neurological symptoms causing suspicion of CNS metastasis; however, the cause of neurological presentation was pre-existing comorbidities.

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References

- Witzel I, Oliveira-Ferrer L, Pantel K, Müller V, Wikman H. Breast cancer brain metastases: biology and new clinical perspectives. Breast Cancer Res. 2016 Dec 1; 18(1): 8.

- Wiens AL, Martin SE, Bertsch EC, Vance GH, Stohler RA, Cheng L, et al. Luminal subtypes predict improved survival following central nervous system metastasis in patients with surgically managed metastatic breast carcinoma. Arch Pathol Lab Med. 2014 Feb; 138(2): 175-81.

- Soni A, Ren Z, Hameed O, Chanda D, Morgan CJ, Siegal GP, et al. Breast cancer subtypes predispose the site of distant metastases. Am J Clin Pathol. 2015 Apr 1; 143(4): 471-8.

- Martin AM, Cagney DN, Catalano PJ, Warren LE, Bellon JR, Punglia RS, et al. Brain metastases in newly diagnosed breast cancer: a population-based study. JAMA Oncol. 2017 Aug 1; 3(8): 1069-77.

- Lin NU, Gaspar LE, Soffietti R. Breast cancer in the central nervous system: multidisciplinary considerations and management. Am Soc Clin Oncol Educ Book. 2017 Jan 1; 37,pp: 45-56.

- Kozak MM, Jacobson CE, von Eyben R, Walck E, Pollom EL, Telli M, et al. Patterns of distant failure by intrinsic breast cancer subtype in premenopausal women treated with neoadjuvant chemotherapy. Clin breast cancer. 2018 Oct 1; 18(5): e1077-85.

- Foulkes WD, Stefansson IM, Chappuis PO, Bégin LR, Goffin JR, Wong N, et al. Germline BRCA1 mutations and a basal epithelial phenotype in breast cancer. JNCI: J Natl Cancer Inst. 2003 Oct 1; 95(19): 1482-5.

- Lakhani SR, Reis-Filho JS, Fulford L, Penault-Llorca F, van der Vijver M, Parry S, et al. Prediction of BRCA1 status in patients with breast cancer using estrogen receptor and basal phenotype. Clin cancer Res. 2005 Jul 15; 11(14): 5175-80.

- Li R, Zhang K, Siegal GP, Wei S. Clinicopathological factors associated with survival in patients with breast cancer brain metastasis. Hum Pathol. 2017 Jun 1; 64: 53-60.

- Eichler AF, Kuter I, Ryan P, Schapira L, Younger J, Henson JW. Survival in patients with brain metastases from breast cancer: the importance of HER‐2 status. Cancer: Interdiscip Int J Am Cancer Soc. 2008 Jun 1; 112(11): 2359-67.