Comparison of High Density Lipid (Hdl) Cholesterol Levels In Acute Ischemic Stroke Patients with and Without Diabetes Mellitus
DOI:
https://doi.org/10.51253/pafmj.v75iSUPPL-4.6489Keywords:
Acute ischemic stroke, Atherosclerosis, Diabetes, Disability adjusted life years (DALY’s), High density lipoprotein cholesterol (HDL cholesterol).Abstract
Objective: To compare HDL cholesterol levels among acute ischemic stroke patient with and without diabetes at tertiary care hospital of Rawalpindi.
Study Design: Cross sectional study.
Place And Duration of Study: Department of Neurology Pak Emirates Military Hospital Rawalpindi, Pakistan from Sep 2020 to Feb 2021.
Methodology: A total of 384 acute ischemic stroke patients were included in this study and non-probability convenience sampling technique was used to complete sample size for this study. A structured questionnaire was used for data collection. Data collected from available lab/hospital ward record and attendant. HDL cholesterol levels were compared between patients with diabetes and without diabetes among acute ischemic stroke patients.
Results: Study showed that overall sixty-two percent (62%) of acute ischemic stroke patients had diabetes and seventy-eight percent (78%) had low HDL cholesterol levels. Independent sample t-test showed significant association between HDL cholesterol level among acute ischemic stroke patients with diabetes (M = 0.77, S.D = 0.24) and with-out diabetes (M = 1.08, S.D = 0.44), p-value < 0.001.
Conclusion: Overall results of this study showed that diabetes does have significant association with HDL cholesterol levels among acute ischemic stroke patients.
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References
Khealani BA, Hameed B, Mapari UU. Stroke in Pakistan [Internet]. Org.pk. [cited 2021 Apr 29]. Available from:
https://jpma.org.pk/PdfDownload/1444.
World health organization - eastern Mediterranean region [Internet]. Who.int. [cited 2021 Apr 29]. Available from: http://www.emro.who.int/health-topics/stroke-cerebrovascular-accident/index.html.
Sacco RL, Kasner SE, Broderick JP, Caplan LR, Connors JJB, Culebras A, et al. An updated definition of stroke for the 21st century: a statement for healthcare professionals from the American Heart Association/American Stroke Association: A statement for healthcare professionals from the American heart association/American stroke association. Stroke. 2013; 44(7): 2064–89.
Stam J. Thrombosis of the cerebral veins and sinuses. N Engl J Med. 2005; 352(17): 1791–8.
Rye K-A, Bursill CA, Lambert G, Tabet F, Barter PJ. The metabolism and anti-atherogenic properties of HDL. J Lipid Res. 2009; 50 Suppl(Supplement): S195-200.
HDL (good), LDL (bad) cholesterol and triglycerides [Internet]. Heart.org. [cited 2021 Apr 30]. Available from: https://www.heart.org/en/health-topics/cholesterol/hdl-good-ldl-bad-cholesterol-and-triglycerides.
Rohatgi A, Khera A, Berry JD, Givens EG, Ayers CR, Wedin KE, et al. HDL cholesterol efflux capacity and incident cardiovascular events. N Engl J Med. 2014; 371(25): 2383–93.
Shen Y, Shi L, Nauman E, Katzmarzyk PT, Price-Haywood EG, Bazzano AN, et al. Inverse association between HDL (high-density lipoprotein) cholesterol and stroke risk among patients with type 2 diabetes mellitus. Stroke. 2019; 50(2): 291–7.
Curb JD, Abbott RD, Rodriguez BL, Masaki KH, Chen R, Popper JS, et al. High density lipoprotein cholesterol and the risk of stroke in elderly men: the Honolulu heart program. Am J Epidemiol. 2004; 160(2): 150–7.
Zeljkovic A, Vekic J, Spasojevic-Kalimanovska V, Jelic-Ivanovic Z, Bogavac-Stanojevic N, Gulan B, et al. LDL and HDL subclasses in acute ischemic stroke: prediction of risk and short-term mortality. Atherosclerosis. 2010; 210(2): 548–54.
Sabahelkhier MK, Awadllah MA, Mohammed Idrees AS, Abel Rahheem Mohammed AA-G, Idris MAR. A study of lipid profile Levels of Type II Diabetes Mellitus. Nova J Med Biol Sci [Internet]. 2016; 5(2). Available from: http://dx.doi.org/10.20286/nova-jmbs-050203.
Luo Y, Li J, Zhang J, Xu Y. Low HDL cholesterol is correlated to the acute ischemic stroke with diabetes mellitus. Lipids Health Dis. 2014; 13(1): 171.
Zhang Y, Tuomilehto J, Jousilahti P, Wang Y, Antikainen R, Hu G. Total and high-density lipoprotein cholesterol and stroke risk. Stroke. 2012; 43(7): 1768–74.
Sacco RL, Benson RT, Kargman DE, Boden-Albala B, Tuck C, Lin I-F, et al. High-density lipoprotein cholesterol and ischemic stroke in the elderly: The northern Manhattan stroke study. JAMA. 2001; 285(21): 2729.
Rothbard G, MS. Association between HDL-C levels, variability, and risk for stroke, myocardial infarction, and mortality [Internet]. Thecardiologyadvisor.com. 2020 [cited 2021 Apr 30]. Available from: https://www.thecardiologyadvisor.com/home/topics/metabolic/dyslipidemia/low-mean-levels-and-high-variability-of-hdl-c-associated-with-increased-risks-for-stroke-myocardial-infarction-and-death/.
Qian Y, Pu Y, Liu L, Wang DZ, Zhao X, Wang C, et al. Low HDL-C level is associated with the development of intracranial artery stenosis: Analysis from the Chinese IntraCranial AtheroSclerosis (CICAS) study. PLoS One. 2013; 8(5): e64395.
Bots ML, Elwood PC, Nikitin Y, Salonen JT, Freire de Concalves A, Inzitari D, et al. Total and HDL cholesterol and risk of stroke. EUROSTROKE: a collaborative study among research centres in Europe. J Epidemiol Community Health. 2002; 56(Supplement 1): i19–24.
Amarenco P, Labreuche J, Touboul P-J. High-density lipoprotein-cholesterol and risk of stroke and carotid atherosclerosis: a systematic review. Atherosclerosis. 2008; 196(2): 489–96
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Copyright (c) 2025 Sarah Khan, Malik Nadeem Azam Khan, Natasha Sarwar, Ambreen Nawaz, Muhammad Zahid Hussain, Hamid Mukhtar Butt
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