Association of Hyperuricemia and Albuminuria with Presence of Cardiovascular Complications Among Patients of Type-II Diabetes Mellitus

Muhammad Faheem; Syed Ali Ghawas; Kiran Nisa; Asif Ali; Muhammad Mamoon Mujahid; Muhammad Zeeshan Akram

doi:10.51253/pafmj.v75iSUPPL-5.9162

Authors

Muhammad Faheem Department of Medicine, 2 Mountain Medical Battalion Kotli Pakistan
Syed Ali Ghawas Department of Medicine, Combined Military Hospital, Skardu /National University of Medical Sciences (NUMS) Pakistan
Kiran Nisa Department of Medicine, 2 Mountain Medical Battalion Kotli Pakistan
Asif Ali Department of Medicine, Pakistan Navy Station Shifa Hospital, Karachi Pakistan
Muhammad Mamoon Mujahid Department of Medicine, 130 Medical Battalion, Pakistan
Muhammad Zeeshan Akram Department of Medicine, Combined Military Hospital, Malir/National University of Medical Sciences (NUMS) Pakistan

DOI:

https://doi.org/10.51253/pafmj.v75iSUPPL-5.9162

Keywords:

Cardiovascular; Microalbuminuria; Type II DM; Uric acid.

Abstract

Objective: To look for association of hyperuricemia, albuminuria and other biochemical markers with presence of cardiovascular complications among patients of type-II Diabetes Mellitus.

Study Design: Comparative cross-sectional study.

Place and Duration of Study: Department of Medicine, PNS Shifa Hospital, Karachi, Pakistan from Jan 2021 to Jun 2021

Methodology: The sample population for this study comprised of patients suffering from type-II diabetes mellitus reporting for routine follow-up visit at medicine department of our hospital. patients were divided into two groups according to presence or absence of cardiovascular complication diagnosed by treating team. Association of uric acid levels, C-reactive protein, LDL-cholesterol and albuminuria was established with presence of cardiovascular complications among the study participants.

Results: Out of 208 patients of type-II diabetes mellitus included in the study, 130(63.3%) were male while 78(36.7%) were female. Mean age of the patients was 45.64±7.764 years. Mean duration of type-II Diabetes Mellitus in the study participants was 4.64±5.67 years. Out of 208 patients, 138(66.3%) patients had no cardiovascular complications while 70(33.7%) patients had any one or more cardiovascular complications. Statistical analysis revealed that hyperuricemia, raised LDL cholesterol levels and albuminuria had statistically significant association with presence of cardiovascular complications (p-value<0.05).

Conclusion: Cardiovascular complications were seen in considerable number of patients managed with type-II diabetes mellitus at our hospital. Presence of albuminuria, raised serum LDL cholesterol levels and hyperuricemia emerged as risk factors for these complications among patients of type-II Diabetes mellitus.

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