COMPARISON OF EFFECT OF HIGH FAT DIET INDUCED OBESITY AND SUBSEQUENT ATORVASTATIN ADMINISTRATION ON DIFFERENT ANTHROPOMETRIC MEASURES IN SPRAGUE DAWLEY RATS

High Fat Diet Induced Obesity And Atorvastatin

Abstract

Objective: To compare the effect of high fat diet induced obesity and atorvastatin administration on different anthropometric parameters in Sprague Dawley rats.
Study Design: Randomized control trial (RCT).
Place and duration of study: The study was conducted at Department of Physiology, Army Medical College Rawalpindi in collaboration with National Institute of Health (NIH) Islamabad and was completed in 12 months.
Material and Methods: Ninety healthy Sprague Dawley rats were taken and divided into three equal groups with 30 rats in each group. Group I rats (normal control) were given normal diet for 3 weeks. Group II rats (obese control) were given high fat diet for 3 weeks. Group III rats (obese treated) were orally given 10mg/kg/day of atorvastatin through gavage method for 3 weeks after obesity induction. At the start of the study, initial body weight and naso-anal length of all the rats in each group were recorded and then weight change was regularly recorded thrice weekly. Naso-anal length was again recorded at the end of the experiment.
Results: There was a significant increase in body weight in high fat diet induced obese and obese atorvastatin treated rats (p<0.05). No significant change in either body mass index or Lee index was observed in any of the groups.
Conclusion: Atorvastatin administration to high fat diet induced obese rats had no significant effect on any of the anthropometric measure of obesity.